Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30245831 | 0.78 | KDM4E (0.77) | BCHEMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL30333093 | 0.78 | MAPK1 (0.50) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL515972 | 0.78 | MAPK1 (0.50) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8880839 | 0.78 | KDM4E (0.77) | BCHEMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8809177 | 0.76 | ALDH1A1 (0.79) | BCHEMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3087486 | 0.76 | FFAR1 (0.53) | MEN1KMT2AKDM4EALDH1A1FFAR1 | |
| SCHEMBL5245979 | 0.76 | ALOX5 (0.47) | — | |
| SCHEMBL2319401 | 0.75 | MTNR1A (0.43) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28519935 | 0.75 | BCHE (0.50) | BCHEMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3684546 | 0.73 | BCHE (0.69) | BCHEMEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |