SCHEMBL3689183

SCHEMBL3689183

CCc1[c]cc(C(F)(F)F)cc1-c1cc([N+](=O)[O-])ccc1Br

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 3/20 0.36
S100A4 P26447 2/20 0.36
KIF11 P52732 2/20 0.35
NOX1 Q9Y5S8 1/20 0.33
BCHE P06276 1/20 0.33
ACHE P22303 1/20 0.33
CES1 P23141 1/20 0.33
P2RX1 P51575 1/20 0.33
TMPRSS4 Q9NRS4 1/20 0.33
CYP3A4 P08684 3/20 0.33
TDP1 Q9NUW8 3/20 0.33
ALDH1A1 P00352 3/20 0.33
AKR1C3 P42330 1/20 0.32
AKR1C2 P52895 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4608374 0.79 VCAM1 (0.37) PTPRCS100A4BCHEACHECES1
SCHEMBL3689185 0.78 AKR1C3 (0.36) PTPRCS100A4BCHEACHECES1
SCHEMBL7741732 0.72 PTPRC (0.63) PTPRCS100A4BCHEACHECES1
SCHEMBL4623845 0.68 PTGDR2 (0.31)
SCHEMBL4608378 0.68 LMNA (0.41) PTPRCS100A4BCHEACHECES1
SCHEMBL455408 0.67 ESR1 (0.32) ALDH1A1
SCHEMBL13043154 0.67 POLB (0.53) PTPRCS100A4ACHECYP3A4TDP1
SCHEMBL85657 0.65 PDE7A (0.50) PTPRCS100A4CYP3A4TDP1ALDH1A1
SCHEMBL4609724 0.65 ALDH1A1 (0.41) PTPRCS100A4CYP3A4TDP1ALDH1A1
SCHEMBL15063901 0.64 HTT (0.53) ACHECYP3A4TDP1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2187748-A2 FUNGICIDAL COMPOUNDS AND MIXTURES E. I. du Pont de Nemours and Company (US) 2010-05-26 EP disclosed
WO-2009055514-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-04-30 WO disclosed