Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 5/20 | 0.48 |
| ▸ | UBE2I | P63279 | 4/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3697615 | 0.92 | HSD17B13 (0.44) | ADORA2AADORA1ADORA3ADORA2BCACNA1B | |
| SCHEMBL3703771 | 0.90 | SCD5 (0.47) | ADORA2AADORA1ADORA3ADORA2BHTT | |
| SCHEMBL3649036 | 0.89 | CACNA1G (0.39) | ADORA2AADORA1ADORA3ADORA2BCACNA1B | |
| SCHEMBL3702682 | 0.89 | ADORA2A (0.47) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL3694815 | 0.86 | ALDH1A1 (0.51) | ADORA2AADORA1ADORA3CACNA1BAPBA1 | |
| SCHEMBL3696233 | 0.86 | PKM (0.49) | ADORA2AADORA1ADORA3ADORA2BCACNA1B | |
| SCHEMBL3703954 | 0.85 | ADORA3 (0.49) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL7490436 | 0.85 | ALDH1A1 (0.48) | ADORA2AADORA1KDM4ESMN1; SMN2HTT | |
| SCHEMBL7487417 | 0.83 | ALDH1A1 (0.47) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL3702560 | 0.83 | ADORA2A (0.46) | ADORA2AADORA1ADORA3CACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | GLAXOSMITHKLINE LLC | 2012-05-17 | — | — | US | disclosed |
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | GLAXOSMITHKLINE LLC | 2012-05-17 | — | — | US | disclosed |
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | GLAXOSMITHKLINE LLC | 2012-05-17 | — | — | US | disclosed |
| US-20090176778-A1 | Certain nitrogen containing bicyclic chemical entities for treating viral infections | GLAXOSMITHKLINE LLC | 2009-07-09 | — | — | US | disclosed |
| US-20090176778-A1 | Certain nitrogen containing bicyclic chemical entities for treating viral infections | GLAXOSMITHKLINE LLC | 2009-07-09 | — | — | US | disclosed |
| WO-2009023179-A2 | NITROGEN CONTAINING BICYCLIC CHEMICAL ENTITIES FOR TREATING VIRAL INFECTIONS | GENELABS TECHNOLOGIES, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | OAT, HAVCR2, CPS1 | ADORA2A 1016/4885ADORA1 2107/4885ADORA3 1474/4885 |
| US-20090176778-A1 | Certain nitrogen containing bicyclic chemical entities for treating viral infections | OAT, HAVCR2, CPS1 | ADORA2A 1016/4885ADORA1 2107/4885ADORA3 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.