Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 6/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707649 | 0.82 | THRB (0.42) | THRBMAPTTHRATSHRSMN1; SMN2 | |
| SCHEMBL3711487 | 0.82 | POLB (0.44) | MAPTALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL3706492 | 0.79 | THRB (0.40) | THRBTHRAKMT2A | |
| SCHEMBL3228633 | 0.76 | THRB (0.51) | THRBTHRAALDH1A1HTTBRD4 | |
| SCHEMBL3704685 | 0.76 | ESRRA (0.44) | THRBMAPTTHRA | |
| SCHEMBL3708122 | 0.76 | THRB (0.45) | THRBTHRASTAT3 | |
| SCHEMBL3705716 | 0.75 | THRB (0.46) | THRBTHRASTAT3 | |
| SCHEMBL3712191 | 0.75 | THRA (0.51) | THRBTHRA | |
| SCHEMBL3709651 | 0.74 | THRB (0.52) | THRBTHRASTAT3 | |
| SCHEMBL3708160 | 0.74 | THRA (0.61) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |