Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713137 | 0.89 | MAPT (0.46) | MAPTGAASMN1; SMN2TSHR | |
| SCHEMBL3705716 | 0.82 | THRB (0.46) | THRBTHRA | |
| SCHEMBL3702629 | 0.82 | THRB (0.42) | THRBMAPTTHRASMN1; SMN2TSHR | |
| SCHEMBL3706492 | 0.81 | THRB (0.40) | THRBTHRA | |
| SCHEMBL3705084 | 0.81 | TSHR (0.44) | THRBMAPTGAASMN1; SMN2TSHR | |
| SCHEMBL3704685 | 0.78 | ESRRA (0.44) | THRBMAPTTHRA | |
| SCHEMBL3708122 | 0.78 | THRB (0.45) | THRBTHRA | |
| SCHEMBL3709651 | 0.76 | THRB (0.52) | THRBTHRA | |
| SCHEMBL3708160 | 0.76 | THRA (0.61) | THRBTHRA | |
| SCHEMBL3209980 | 0.76 | THRB (0.55) | THRBTHRATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |