Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705084 | 0.84 | TSHR (0.44) | POLBSMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL3711114 | 0.83 | TSHR (0.44) | TP53SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL3702629 | 0.82 | THRB (0.42) | SMN1; SMN2KMT2ATSHRBRD4BRD3 | |
| SCHEMBL3705439 | 0.80 | TSPO (0.38) | KMT2AMEN1TSHRALDH1A1LMNA | |
| SCHEMBL3707230 | 0.80 | LMNA (0.36) | TP53KMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL3231409 | 0.79 | POLB (0.45) | POLBTP53CASP1SMN1; SMN2KMT2A | |
| SCHEMBL3706682 | 0.78 | THRB (0.39) | LMNAMAPT | |
| SCHEMBL3703153 | 0.78 | THRB (0.45) | — | |
| SCHEMBL3715784 | 0.78 | TSHR (0.39) | KMT2AMEN1TSHRLMNAMAPT | |
| SCHEMBL3714771 | 0.78 | ESR1 (0.38) | SMN1; SMN2KMT2AMEN1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |