Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 4/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708830 | 0.80 | PIN1 (0.49) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL3705907 | 0.78 | MAOA (0.42) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL15146279 | 0.73 | AURKA (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27244007 | 0.69 | STK17B (0.43) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL30881391 | 0.69 | STK17B (0.43) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL14516645 | 0.69 | KCNQ3 (0.72) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL17623633 | 0.68 | STK17B (0.57) | MEN1KMT2AMAPTHTT | |
| SCHEMBL27243764 | 0.67 | NPC1 (0.47) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL2287134 | 0.67 | MAOA (0.68) | KDM4EHDAC1HDAC2MAOAGAA | |
| SCHEMBL25981388 | 0.67 | NPC1 (0.59) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |