Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 3/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149617 | 0.78 | HSD11B1 (0.36) | ALDH1A1RAB9ANPC1PLA2G1BATG4B | |
| SCHEMBL8256735 | 0.71 | MAOA (0.44) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL879050 | 0.70 | CDC25B (0.39) | ALDH1A1RAB9ANPC1PLA2G1BCASP3 | |
| SCHEMBL29492985 | 0.70 | CDC25B (0.39) | ALDH1A1RAB9ANPC1PLA2G1BCASP3 | |
| SCHEMBL14374853 | 0.70 | PLEC (0.39) | ALDH1A1RAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL3745024 | 0.67 | SMN1; SMN2 (0.38) | ALDH1A1RAB9ANPC1PLA2G1BCASP3 | |
| SCHEMBL8258013 | 0.65 | PKM (0.49) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL3697487 | 0.65 | MEN1 (0.39) | RAB9ANPC1PLA2G1BCASP3ATG4B | |
| SCHEMBL2026326 | 0.65 | MEN1 (0.39) | ALDH1A1RAB9ANPC1PLA2G1BATG4B | |
| SCHEMBL31131321 | 0.65 | LMNA (0.45) | ALDH1A1RAB9ANPC1PLA2G1BATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391602-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010080481-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |
| US-7312211-B2 | Pryanone compounds useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2007-12-25 | — | — | US | disclosed |
| US-7312211-B2 | Pryanone compounds useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2007-12-25 | — | — | US | disclosed |