Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 5/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15662782 | 0.84 | KMT2A (0.45) | NR1H4MAPTPLAU | |
| SCHEMBL10287469 | 0.82 | PLA2G2A (0.49) | RARB | |
| SCHEMBL3714048 | 0.82 | TAS1R3 (0.40) | KDM4EPLAU | |
| SCHEMBL3216400 | 0.81 | TAS1R3 (0.39) | KDM4EPLAU | |
| SCHEMBL20606774 | 0.81 | PLAU (0.43) | PLAULTB4R | |
| SCHEMBL899603 | 0.80 | MAPT (0.50) | MAPTPLAU | |
| SCHEMBL8386250 | 0.79 | ALOX5 (0.43) | MAPK1ALOX5PPARGTHRATHRB | |
| SCHEMBL2658290 | 0.77 | KMT2A (0.43) | MAPK1XDHKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8382888 | 0.77 | PPARG (0.42) | MAPK1ALOX5PPARGTHRATHRB | |
| SCHEMBL3936715 | 0.76 | ALDH1A1 (0.51) | MAPTL3MBTL1PLAULTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |