Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216400 | 0.93 | TAS1R3 (0.39) | TAS1R3TAS1R1TAS1R2PLAUHCAR3 | |
| SCHEMBL15662782 | 0.86 | KMT2A (0.45) | PLAUALDH1A1KDM4CPLA2G2A | |
| SCHEMBL10287469 | 0.85 | PLA2G2A (0.49) | PLA2G2A | |
| SCHEMBL20606774 | 0.83 | PLAU (0.43) | TAS1R3TAS1R1TAS1R2PLAUTPMT | |
| SCHEMBL15295880 | 0.83 | GPR119 (0.45) | KDM4EALDH1A1 | |
| SCHEMBL899603 | 0.83 | MAPT (0.50) | PLAUTPMTPLA2G2A | |
| SCHEMBL3713481 | 0.82 | MAPK1 (0.50) | PLAUKDM4E | |
| SCHEMBL837798 | 0.80 | ALDH1A1 (0.56) | TAS1R3TAS1R1TAS1R2KDM4EALDH1A1 | |
| SCHEMBL30016380 | 0.79 | FFAR4 (0.37) | HCAR3KDM4EALDH1A1FFAR4PLA2G2A | |
| SCHEMBL28634663 | 0.79 | FFAR4 (0.37) | HCAR3KDM4EALDH1A1FFAR4PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663511-B2 | Sphingosine 1-phosphate receptor antagonists | Arroyo BioSciences, LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663511-B2 | Sphingosine 1-phosphate receptor antagonists | Arroyo BioSciences, LLC (US) | 2017-05-30 | — | — | US | disclosed |
| EP-2831072-B1 | NOVEL SPHINGOSINE 1-PHOSPHATE RECEPTOR ANTAGONISTS | ARROYO BIOSCIENCES L L C (US) | 2017-04-19 | — | — | EP | disclosed |
| US-20150045332-A1 | Novel Sphingosine 1-Phosphate Receptor Antagonists | ARROYO BIOSCIENCES L.L.C. | 2015-02-12 | — | — | US | disclosed |
| US-20150045332-A1 | Novel Sphingosine 1-Phosphate Receptor Antagonists | ARROYO BIOSCIENCES L.L.C. | 2015-02-12 | — | — | US | disclosed |
| WO-2014158302-A1 | NOVEL SPHINGOSINE 1-PHOSPHATE RECEPTOR ANTAGONISTS | SWENSON ROLF ERIC (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2013148460-A1 | NOVEL SPHINGOSINE 1-PHOSPHATE RECEPTOR ANTAGONISTS | SWENSON ROLF E (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045332-A1 | Novel Sphingosine 1-Phosphate Receptor Antagonists | S1PR2, S1PR1, S1PR5 | TAS1R3 1890/4885TAS1R1 1121/4885TAS1R2 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.