Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19330178 | 0.89 | MAPT (0.59) | MAPTPOLBALOX15HTTTDP1 | |
| SCHEMBL15662782 | 0.87 | KMT2A (0.45) | MAPTHTTLMNAKMT2ATDP1 | |
| SCHEMBL10287469 | 0.86 | PLA2G2A (0.49) | POLBMEN1KMT2ATSHRPLA2G2A | |
| SCHEMBL1314039 | 0.84 | GPR119 (0.49) | POLBMEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL19330396 | 0.83 | KDM4E (0.55) | MAPTLMNATDP1TSHRPLA2G2A | |
| SCHEMBL3714048 | 0.83 | TAS1R3 (0.40) | TPMTPLA2G2APLAU | |
| SCHEMBL3216400 | 0.81 | TAS1R3 (0.39) | POLBGAAKMT2ATDP1TPMT | |
| SCHEMBL1424858 | 0.81 | MAPT (0.51) | MAPTPOLBALOX15HTTLMNA | |
| SCHEMBL19354063 | 0.81 | MAPT (0.51) | MAPTPOLBHTTMEN1LMNA | |
| SCHEMBL837798 | 0.81 | ALDH1A1 (0.56) | POLBALOX15LMNATDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322777-A1 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | PFIZER INC. (US) | 2023-10-12 | — | — | US | disclosed |
| US-11673890-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20210047325-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2021-02-18 | — | — | US | disclosed |
| US-10822335-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190218218-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2019-07-18 | — | — | US | disclosed |
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2019-05-21 | — | — | US | disclosed |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2018-06-14 | — | — | US | disclosed |
| US-9908883-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2018-03-06 | — | — | US | disclosed |
| US-9663511-B2 | Sphingosine 1-phosphate receptor antagonists | Arroyo BioSciences, LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663511-B2 | Sphingosine 1-phosphate receptor antagonists | Arroyo BioSciences, LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-8703797-B2 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors | ALLERGAN, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20130296361-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | ALLERGAN, INC. | 2013-11-07 | — | — | US | disclosed |
| WO-2013148460-A1 | NOVEL SPHINGOSINE 1-PHOSPHATE RECEPTOR ANTAGONISTS | SWENSON ROLF E (US) | 2013-10-03 | — | — | WO | disclosed |
| US-8507682-B2 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P2) receptors | ALLERGAN, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| EP-2621493-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | Pfizer Inc (US) | 2013-08-07 | — | — | EP | disclosed |
| US-20130190334-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20120208840-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | ALLERGAN, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| EP-2483245-A1 | CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS | Allergan, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2012042433-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011041287-A1 | CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS | ALLERGAN, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190334-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | MAPT 1882/4885POLB 1613/4885ALOX15 1039/4885 |
| US-20230322777-A1 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, ACACB, PC | MAPT 1409/4885POLB 1523/4885ALOX15 1340/4885 |
| US-11673890-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | MAPT 1417/4885POLB 1659/4885ALOX15 1337/4885 |
| US-20190218218-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | MAPT 1494/4885POLB 1639/4885ALOX15 1325/4885 |
| US-20130296361-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | S1PR1, S1PR2, S1PR3 | MAPT 4756/4885POLB 3462/4885ALOX15 889/4885 |
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | MAPT 1409/4885POLB 1523/4885ALOX15 1340/4885 |
| US-20210047325-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | MAPT 1417/4885POLB 1659/4885ALOX15 1337/4885 |
| US-20120208840-A1 | Condensed Ring Pyridine Compounds As Subtype-Selective Modulators Of Sphingosine-1-Phosphate-2 (S1P2) Receptors | S1PR1, S1PR2, S1PR3 | MAPT 4756/4885POLB 3462/4885ALOX15 889/4885 |
| US-10822335-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | MAPT 1409/4885POLB 1523/4885ALOX15 1340/4885 |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | MAPT 1409/4885POLB 1523/4885ALOX15 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.