Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714828 | 0.86 | KDM4E (0.46) | HPGDKDM4EL3MBTL1POLBADORA2A | |
| SCHEMBL3711261 | 0.80 | CASP1 (0.42) | HPGDKDM4EL3MBTL1POLBALDH1A1 | |
| SCHEMBL10756170 | 0.78 | TACR3 (0.59) | HPGDKDM4EL3MBTL1POLBALDH1A1 | |
| SCHEMBL3717261 | 0.78 | MAPT (0.53) | HPGDKDM4EL3MBTL1POLBALDH1A1 | |
| SCHEMBL3711258 | 0.77 | DCTPP1 (0.47) | HPGDKDM4EL3MBTL1POLBALDH1A1 | |
| SCHEMBL3709546 | 0.77 | ALDH1A1 (0.59) | HPGDKDM4EPOLBALDH1A1GLA | |
| SCHEMBL3719963 | 0.77 | ALDH1A1 (0.56) | HPGDKDM4EL3MBTL1POLBALDH1A1 | |
| SCHEMBL3713427 | 0.76 | KDM4E (0.46) | HPGDKDM4EL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL3710606 | 0.75 | GRM5 (0.42) | HPGDKDM4EL3MBTL1POLBADORA3 | |
| SCHEMBL3709285 | 0.74 | KDM4E (0.43) | KDM4EPOLBALDH1A1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |