Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714094 | 0.88 | MAPT (0.53) | MAPTL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3711258 | 0.82 | DCTPP1 (0.47) | MAPTL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL11861385 | 0.80 | GAA (0.66) | MAPTL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3713427 | 0.79 | KDM4E (0.46) | MAPTL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL9266977 | 0.78 | HTT (0.57) | MAPTL3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3711261 | 0.78 | CASP1 (0.42) | L3MBTL1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3719963 | 0.78 | ALDH1A1 (0.56) | MAPTL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL3709546 | 0.78 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL3715096 | 0.78 | HPGD (0.45) | L3MBTL1KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL3714526 | 0.76 | PLA2G2A (0.57) | MAPTL3MBTL1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |