Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713454 | 0.86 | DCTPP1 (0.52) | DCTPP1MMP2MMP13MMP14KDM4E | |
| SCHEMBL3711261 | 0.84 | CASP1 (0.42) | MMP13KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3717261 | 0.82 | MAPT (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL3713520 | 0.79 | GRM5 (0.46) | DCTPP1MMP2MMP13MMP14KDM4E | |
| SCHEMBL3715096 | 0.77 | HPGD (0.45) | KDM4EALDH1A1HPGDCCR6MAPK1 | |
| SCHEMBL3709546 | 0.77 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL3719963 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL3713427 | 0.76 | KDM4E (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL3714526 | 0.75 | PLA2G2A (0.57) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL3517715 | 0.75 | RAB9A (0.59) | DCTPP1MMP2MMP13MMP14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |