Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715292 | 0.82 | PPARG (0.41) | MAPTKDM4E | |
| SCHEMBL3716544 | 0.81 | HTR2A (0.33) | LMNAMAPTKDM4EALDH1A1TP53 | |
| SCHEMBL1708399 | 0.78 | TSHR (0.38) | LMNAMAPTTSHRALDH1A1GAA | |
| SCHEMBL1708112 | 0.78 | TSHR (0.38) | LMNAMAPTTSHRALDH1A1GAA | |
| SCHEMBL1707944 | 0.78 | TSHR (0.38) | LMNAMAPTTSHRALDH1A1GAA | |
| SCHEMBL1708166 | 0.77 | LMNA (0.36) | LMNAMAPTTSHRALDH1A1TP53 | |
| SCHEMBL1708168 | 0.77 | NTRK1 (0.36) | LMNAMAPTTSHRALDH1A1GAA | |
| SCHEMBL1707942 | 0.77 | NTRK1 (0.36) | LMNAMAPTTSHRALDH1A1GAA | |
| SCHEMBL1707749 | 0.76 | MAPT (0.34) | LMNAMAPTKDM4EALDH1A1TP53 | |
| SCHEMBL1708628 | 0.76 | MAPT (0.32) | LMNAMAPTTSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |