Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.47 |
| ▸ | CDK9 | P50750 | 6/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.47 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.44 |
| ▸ | CDK7 | P50613 | 4/20 | 0.44 |
| ▸ | CCNH | P51946 | 4/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718696 | 0.89 | CDK2 (0.43) | CDK2CCNE1CDK9CCNT1CCNE2 | |
| SCHEMBL3720176 | 0.86 | TACR2 (0.49) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| SCHEMBL3724482 | 0.85 | CDK2 (0.51) | CDK2CCNE1CDK9CCNT1CCNE2 | |
| SCHEMBL3726417 | 0.84 | TACR2 (0.42) | CDK2CCNE1CDK9CCNE2CDK5 | |
| SCHEMBL3719064 | 0.83 | CYP3A4 (0.43) | CDK2CCNE1CCNE2CDK5TACR2 | |
| SCHEMBL3721963 | 0.81 | P2RX7 (0.41) | CDK2CCNE1CCNE2CDK5TACR2 | |
| SCHEMBL3714767 | 0.81 | CDK2 (0.43) | CDK2CCNE1CCNE2CDK5TACR2 | |
| SCHEMBL3719455 | 0.81 | CDK2 (0.52) | CDK2CCNE1CDK9CCNT1CCNE2 | |
| SCHEMBL3716187 | 0.81 | CDK2 (0.43) | CDK2CCNE1CCNE2CDK5CDK5R1 | |
| SCHEMBL2910733 | 0.80 | CDK2 (0.52) | CDK2CCNE1CDK9CCNT1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139288-A1 | 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS | C3 BIO GMBH (DE) | 2010-12-09 | — | — | WO | disclosed |