Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | FABP4 | P15090 | 2/20 | 0.57 |
| ▸ | WDR5 | P61964 | 1/20 | 0.57 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.56 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556993 | 0.90 | SLC22A12 (0.54) | SLC22A12ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL3555827 | 0.84 | PKLR (0.53) | SLC22A12ALDH1A1MEN1KMT2AALKBH2 | |
| SCHEMBL3562430 | 0.84 | IDH1 (0.53) | SLC22A12ALDH1A1MEN1KMT2AALKBH2 | |
| SCHEMBL3769130 | 0.83 | SLC22A12 (0.70) | SLC22A12ALDH1A1MEN1KMT2A | |
| SCHEMBL4397021 | 0.81 | FABP4 (0.62) | ALDH1A1MEN1KMT2AFABP4WDR5 | |
| SCHEMBL3560911 | 0.80 | MEN1 (0.57) | SLC22A12ALDH1A1MEN1KMT2A | |
| SCHEMBL13811849 | 0.80 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2AFABP4WDR5 | |
| SCHEMBL3726033 | 0.80 | SLC22A12 (0.65) | SLC22A12ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL3555598 | 0.79 | PKLR (0.58) | SLC22A12ALDH1A1MEN1KMT2AALKBH2 | |
| SCHEMBL5212720 | 0.78 | HTR1F (0.53) | SLC22A12HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |