Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721758 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1PTPN1KMT2AMEN1 | |
| SCHEMBL3726441 | 0.70 | RAB9A (0.38) | KDM4EMAPT | |
| SCHEMBL1390796 | 0.70 | MEN1 (0.35) | ALDH1A1PTPN1KMT2AMEN1MAPT | |
| SCHEMBL3716940 | 0.67 | ACACB (0.42) | MAPT | |
| SCHEMBL3726994 | 0.65 | ACACB (0.42) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL27708666 | 0.62 | PTGS2 (0.57) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3726439 | 0.62 | ACACB (0.39) | KDM4EKMT2AMEN1MAPTKCNH2 | |
| SCHEMBL23014458 | 0.60 | TP53 (0.46) | ALDH1A1KMT2AMEN1MAPTTP53 | |
| SCHEMBL6725914 | 0.60 | PDE7A (0.66) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| Nitrofen SCHEMBL28995202 | 0.59 | PDE7A (0.58) | KDM4EALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |