Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.38 |
| ▸ | CTSS | P25774 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | AOC2 | O75106 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718383 | 0.89 | CTSS (0.36) | RORCCTSSAOC2MAOAP2RX7 | |
| SCHEMBL3725935 | 0.86 | P2RX7 (0.43) | RORCP2RX7HSD11B1 | |
| SCHEMBL3719493 | 0.83 | CTSS (0.37) | RORCCTSSHSD11B1 | |
| SCHEMBL697204 | 0.82 | KEAP1 (0.37) | RORCHCRTR1HCRTR2 | |
| SCHEMBL690481 | 0.82 | TSHR (0.36) | CTSSP2RX7HSD11B1 | |
| SCHEMBL696119 | 0.81 | HSD11B1 (0.41) | RORCCTSSCTSLP2RX7HSD11B1 | |
| SCHEMBL694889 | 0.79 | P2RX7 (0.40) | RORCCTSSCTSLP2RX7HCRTR1 | |
| SCHEMBL3719407 | 0.78 | CFTR (0.36) | RORCHSD11B1 | |
| SCHEMBL695720 | 0.76 | CTSS (0.37) | CTSSP2RX7HSD11B1KCNJ6KCNJ5 | |
| SCHEMBL694457 | 0.76 | AADAT (0.36) | CTSSITGB1ITGA4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |