SCHEMBL3723757 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	VNN1	O95497	2/20	0.40

▸	HPGD	P15428	1/20	0.37

▸	ADORA2B	P29275	9/20	0.36

▸	ADORA2A	P29274	2/20	0.36

▸	HDAC4	P56524	1/20	0.36

▸	APOBEC3A	P31941	1/20	0.35

▸	APOBEC3G	Q9HC16	1/20	0.35

▸	RAB9A	P51151	1/20	0.34

▸	ATR	Q13535	1/20	0.34

▸	ADORA3	P0DMS8	1/20	0.34

▸	KMT2A	Q03164	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9044008	0.75	DPP4 (0.48)	VNN1HPGDADORA2BADORA2AHDAC4
SCHEMBL3715622	0.75	POLB (0.43)	HPGDAPOBEC3AAPOBEC3GKMT2A
SCHEMBL9044128	0.73	VNN1 (0.40)	VNN1HPGDADORA2BADORA2AHDAC4
SCHEMBL3716813	0.70	ALDH1A1 (0.44)	—
SCHEMBL4053920	0.67	HDAC4 (0.48)	VNN1HDAC4
SCHEMBL28089590	0.67	HDAC4 (0.48)	VNN1HDAC4
SCHEMBL4458413	0.67	PDK2 (0.43)	VNN1HPGDADORA2BHDAC4RAB9A
SCHEMBL7381076	0.67	L3MBTL1 (0.66)	VNN1KMT2A
SCHEMBL29688509	0.67	L3MBTL1 (0.66)	VNN1KMT2A
SCHEMBL8924724	0.66	KDM4E (0.41)	KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2010131145-A1	CYCLOBUTENEDIONE DERIVATIVES	PFIZER LIMITED (GB)	2010-11-18	—	—	WO	disclosed