Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22840303 | 0.80 | APOBEC3A (0.55) | DPP4NEK2HPGD | |
| SCHEMBL9045289 | 0.77 | KMT2A (0.54) | DPP4ATRHPGDPIM1PIM3 | |
| SCHEMBL9044128 | 0.77 | VNN1 (0.40) | VNN1ADORA2BHPGDADORA2AHDAC4 | |
| SCHEMBL3723757 | 0.75 | VNN1 (0.40) | ATRVNN1ADORA2BHPGDADORA2A | |
| SCHEMBL17661022 | 0.73 | DPP4 (0.49) | DPP4ADORA2BADORA2A | |
| SCHEMBL15402120 | 0.72 | PDE10A (0.45) | DPP4ATRADORA2BADORA2A | |
| SCHEMBL19144451 | 0.70 | MGLL (0.55) | ATRHDAC4 | |
| SCHEMBL2993890 | 0.70 | MGLL (0.55) | ATRHDAC4 | |
| SCHEMBL7381076 | 0.70 | L3MBTL1 (0.66) | VNN1 | |
| SCHEMBL29688509 | 0.70 | L3MBTL1 (0.66) | VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743944-A1 | AZACYCLIC DERIVATIVES | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021843-A1 | AZACYCLIC DERIVATIVES | SMITHKLINE BEECHAM FARMACEUTICI S.P.A. (IT) | 1995-08-17 | — | — | WO | disclosed |