SCHEMBL3729918

SCHEMBL3729918

ClC1(c2ccccc2)c2ccccc2Oc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.38
AHR P35869 4/20 0.38
CFTR P13569 1/20 0.34
GOPC Q9HD26 1/20 0.34
MAOA P21397 2/20 0.33
MAOB P27338 2/20 0.33
CHRM3 P20309 1/20 0.33
SLC6A1 P30531 1/20 0.31
P2RX4 Q99571 2/20 0.31
LMNA P02545 1/20 0.31
PNMT P11086 1/20 0.30
P2RX1 P51575 1/20 0.30
P2RX3 P56373 1/20 0.30
P2RX7 Q99572 1/20 0.30
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21880277 0.83 LMNA (0.37) ALOX5AHRMAOALMNA
SCHEMBL11453271 0.81 CFTR (0.37) CFTRGOPCMAOAMAOBP2RX4
SCHEMBL9407348 0.80 ATM (0.39) MAOAMAOBP2RX4
SCHEMBL5467986 0.77 GAA (0.36) MAOAMAOBLMNAMEN1NPC1
SCHEMBL4388225 0.77 ALOX5 (0.41) ALOX5AHRCFTRGOPCMAOA
SCHEMBL8984710 0.77 ALOX5 (0.44) ALOX5AHRMAOAMAOBCHRM3
SCHEMBL23028838 0.76 LMNA (0.39) ALOX5AHRCFTRGOPCMAOA
SCHEMBL11510200 0.75 S100A4 (0.45) CFTRGOPCLMNAMEN1RAB9A
SCHEMBL896505 0.74 PNMT (0.39) ALOX5AHRCFTRGOPCMAOA
SCHEMBL7031351 0.74 ALOX5 (0.38) ALOX5AHRCFTRGOPCMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113683631-A Organic boric acid glucose probe and preparation method and application thereof 王凯 2021-11-23 CN claimed
US-5663030-A A PHENYL OR NORBORNANE DERIVATIVE AS AN ADDITIVE TO REDUCE HEAT AND ENERGY REQUIRED TO FUSE THE TONER AND TO REDUCE JAMMING OF THE EQUIPMENT XEROX CORPORATION (US) 1997-09-02 US claimed
CN-113683631-B Organic boric acid glucose probe and preparation method and application thereof 王凯 2023-01-17 CN disclosed
US-11390643-B2 Modified oligonucleotides comprising thiol functions and use thereof for detecting nucleic acids ETABLISSEMENT FRANÇAIS DU SANG (FR) 2022-07-19 US disclosed
CN-113683631-A Organic boric acid glucose probe and preparation method and application thereof 王凯 2021-11-23 CN disclosed
US-11078229-B2 Thiol compounds and the use thereof for the synthesis of modified oligonucleotides CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2021-08-03 US disclosed
US-20180265538-A1 THIOL COMPOUNDS AND THE USE THEREOF FOR THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2018-09-20 US disclosed
US-9896473-B2 Thiol compounds and the use thereof for the synthesis of modified oligonucleotides ETABLISSEMENT FRANCAIS DU SANG (FR) 2018-02-20 US disclosed
US-20150232957-A1 MODIFIED OLIGONUCLEOTIDES COMPRISING THIOL FUNCTIONS AND USE THEREOF FOR DETECTING NUCLEIC ACIDS ETABLISSEMENT FRANÇAIS DU SANG (FR) 2015-08-20 US disclosed
US-20150158964-A1 THIOL COMPOUNDS AND THE USE THEREOF FOR THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES UNIVERSITE CLAUDE BERNARD LYON 1 (FR) 2015-06-11 US disclosed
US-8785419-B2 Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2014-07-22 US disclosed
US-5387725-A Chlorinating compounds having acidic protons with a perchloro-alkane and aqueous base in the presence of a tetraalkyl-ammonium hydroxide phase transfer catalyst THE DOW CHEMICAL COMPANY (US) 1995-02-07 US disclosed
CN-1098107-A modified oligodeoxynucleotides, their preparation and their therapeutic use SANKYO CO (JP) 1995-02-01 CN disclosed
EP-0624372-A2 Medicament for treating human immunodeficiency virus NIPPON CHEMIPHAR CO., LTD. (JP) 1994-11-17 EP disclosed
EP-0617046-A1 Nucleoside derivatives and antiherpes composition NIPPON CHEMIPHAR CO., LTD. (JP) 1994-09-28 EP disclosed
EP-0611366-A1 CHLORINATION PROCESS, ALKYLATION OF PRODUCTS OF SAID PROCESS AND SOME PRODUCTS THEREOF THE DOW CHEMICAL COMPANY (US) 1994-08-24 EP disclosed
EP-0611075-A1 Modified oligodeoxyribonucleotides, their preparation and their therapeutic use SANKYO COMPANY LIMITED (JP) 1994-08-17 EP disclosed
WO-1993024511-A1 OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) 1993-12-09 WO disclosed
WO-1993009074-A2 CHLORINATION PROCESS, ALKYLATION OF PRODUCTS OF SAID PROCESS AND SOME PRODUCTS THEREOF THE DOW CHEMICAL COMPANY (US) 1993-05-13 WO disclosed
EP-0513358-A1 PROCESS FOR PRODUCING CYCLODEXTRIN DERIVATIVE AND POLYMER CONTAINING CYCLODEXTRIN IMMOBILIZED THEREIN Toppan Printing Co., Ltd. (JP) 1992-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150158964-A1 THIOL COMPOUNDS AND THE USE THEREOF FOR THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES TST, APEX1, TMT1A ALOX5 956/4885AHR 3265/4885CFTR 3167/4885
US-11390643-B2 Modified oligonucleotides comprising thiol functions and use thereof for detecting nucleic acids DNAJC10, TIMCC, TST ALOX5 4140/4885AHR 3099/4885CFTR 956/4885
US-20180265538-A1 THIOL COMPOUNDS AND THE USE THEREOF FOR THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES TST, APEX1, TMT1A ALOX5 956/4885AHR 3265/4885CFTR 3167/4885
US-11078229-B2 Thiol compounds and the use thereof for the synthesis of modified oligonucleotides TST, APEX1, TMT1A ALOX5 956/4885AHR 3265/4885CFTR 3167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.