Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15986584 | 0.82 | NPC1 (0.44) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL4190714 | 0.77 | KDM4E (0.50) | HPGDL3MBTL1MAPK1ALDH1A1NPC1 | |
| SCHEMBL1750892 | 0.77 | MAPT (0.48) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL5795265 | 0.77 | MAPT (0.58) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL4980035 | 0.75 | MAPT (0.46) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL78925 | 0.74 | L3MBTL1 (0.45) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL3660700 | 0.74 | KDM4E (0.50) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL13538059 | 0.73 | MAPT (0.44) | MAPTHPGDL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL29784889 | 0.72 | TSHR (0.44) | HPGDL3MBTL1ALDH1A1NPC1CYP2D6 | |
| SCHEMBL165449 | 0.72 | TSHR (0.44) | HPGDL3MBTL1ALDH1A1NPC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280024-A1 | RENIN INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2010-11-04 | — | — | US | disclosed |
| WO-2010011584-A2 | PROCESS FOR MAKING A RENIN INHIBITOR | MERCK & CO., INC. (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280024-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MAPT 45/4885HPGD 599/4885L3MBTL1 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.