Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.70 |
| ▸ | DRD2 | P14416 | 2/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.70 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.70 |
| ▸ | HTR7 | P34969 | 2/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | DRD4 | P21917 | 1/20 | 0.69 |
| ▸ | FPR3 | P25089 | 1/20 | 0.69 |
| ▸ | HTR1D | P28221 | 1/20 | 0.69 |
| ▸ | HTR1B | P28222 | 1/20 | 0.69 |
| ▸ | GPR183 | P32249 | 1/20 | 0.69 |
| ▸ | HRH1 | P35367 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535261 | 0.91 | HTR1A (0.68) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| SCHEMBL3743559 | 0.87 | HTR1A (0.78) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL16964477 | 0.84 | HTR1A (0.91) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL4423647 | 0.83 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL650682 | 0.83 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL30051446 | 0.83 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357448 | 0.83 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL4552641 | 0.82 | HTR1A (0.97) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL16964001 | 0.82 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Hydrochloric Acid SCHEMBL2201830 | 0.82 | HTR1A (0.88) | HTR1AADRA2ADRD2ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829565-B2 | Indole derivatives as serotonin reuptake inhibitors | MERCK PATENT GMBH (DE) | 2010-11-09 | — | — | US | disclosed |
| US-7829565-B2 | Indole derivatives as serotonin reuptake inhibitors | MERCK PATENT GMBH (DE) | 2010-11-09 | — | — | US | disclosed |
| US-7829565-B2 | Indole derivatives as serotonin reuptake inhibitors | MERCK PATENT GMBH (DE) | 2010-11-09 | — | — | US | disclosed |
| US-20070099933-A1 | Indole derivatives as serotonin reuptake inhibitors | MERCK PATENTGMBH (DE) | 2007-05-03 | — | — | US | disclosed |
| US-20070099933-A1 | Indole derivatives as serotonin reuptake inhibitors | MERCK PATENTGMBH (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099933-A1 | Indole derivatives as serotonin reuptake inhibitors | TPH1, TPH2, HTR5A | HTR1A 4/4885ADRA2A 89/4885DRD2 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.