Sugi Predict

Sugi Predict / Compounds / SCHEMBL374389

SCHEMBL374389

SCHEMBL374389

Cc1ccc([N+](=O)[O-])cc1N=C=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.56
▸ TSHR P16473 3/20 0.56
▸ TDP1 Q9NUW8 3/20 0.56
▸ CYP3A4 P08684 6/20 0.56
▸ TRPA1 O75762 1/20 0.56
▸ LMNA P02545 2/20 0.48
▸ NPC1 O15118 1/20 0.48
▸ MAPK1 P28482 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ PDE2A O00408 1/20 0.44
▸ PDE5A O76074 1/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ NFKB1 P19838 1/20 0.44
▸ APEX1 P27695 1/20 0.44
▸ PDE4A P27815 1/20 0.44
▸ BLM P54132 1/20 0.44
▸ PDE1B Q01064 1/20 0.44
▸ PMP22 Q01453 1/20 0.44
▸ PDE4B Q07343 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8103505 0.91 CYP3A4 (0.47) ALDH1A1TSHRTDP1CYP3A4TRPA1
SCHEMBL546059 0.86 ALDH1A1 (0.56) ALDH1A1TSHRTDP1CYP3A4TRPA1
SCHEMBL3368739 0.85 ALDH1A1 (0.55) ALDH1A1TSHRTDP1CYP3A4LMNA
SCHEMBL8674836 0.84 CYP3A4 (0.41) ALDH1A1TSHRTDP1CYP3A4TRPA1
SCHEMBL11232668 0.81 GPR35 (0.50) ALDH1A1TSHRTDP1CYP3A4LMNA
SCHEMBL11494910 0.80 ALDH1A1 (0.62) ALDH1A1TSHRTDP1CYP3A4LMNA
SCHEMBL1944148 0.79 ALDH1A1 (0.43) ALDH1A1TSHRTDP1CYP3A4TRPA1
SCHEMBL1945604 0.79 TXNRD1 (0.42) ALDH1A1TSHRTDP1CYP3A4LMNA
SCHEMBL1940462 0.79 HSD17B10 (0.56) ALDH1A1TSHRTDP1CYP3A4LMNA
SCHEMBL912939 0.79 ALDH1A1 (0.53) ALDH1A1TSHRTDP1CYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112223861-A Energy-saving silicon phenol fireproof insulation board 广东华瑞环保材料有限公司 2021-01-15 — — CN claimed
CN-113750651-B Filter material with antibacterial and deodorizing functions and preparation method thereof 杭州巴贝克科技有限公司 2023-04-18 — — CN disclosed
US-20230116771-A1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE REGENERON PHARMACEUTICALS, INC. 2023-04-13 — — US disclosed
EP-3408271-B1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE REGENERON PHARMA (US) 2023-01-11 — — EP disclosed
US-11446389-B2 Maytansinoid derivatives, conjugates thereof, and methods of use REGENERON PHARMACEUTICALS, INC. (US) 2022-09-20 — — US disclosed
CN-108779127-B Maytansinoid derivatives, conjugates thereof, and methods of use 里珍纳龙药品有限公司 2022-07-05 — — CN disclosed
CN-114478801-A Maytansinoid derivatives, conjugates thereof, and methods of use 里珍纳龙药品有限公司 2022-05-13 — — CN disclosed
CN-113750651-A Filter material with antibacterial and deodorizing functions and preparation method thereof 杭州巴贝克科技有限公司 2021-12-07 — — CN disclosed
CN-112297321-B Insulation board foaming equipment, insulation board production line and production process 广东华瑞环保材料有限公司 2021-07-20 — — CN disclosed
CN-112223861-B Energy-saving silicon phenol fireproof insulation board 广东华瑞环保材料有限公司 2021-06-22 — — CN disclosed
EP-0816309-A1 Scavenger assisted combinatorial process for preparing libraries of urea and thiourea compounds ELI LILLY AND COMPANY (US) 1998-01-07 — — EP disclosed
EP-0194023-A1 Process for the electrochemical carbonylation of aromatic nitro compounds TEXACO DEVELOPMENT CORPORATION (US) 1986-09-10 — — EP disclosed
US-4515813-A REDUCED PHYTOTOXICITY STAUFFER CHEMICAL COMPANY (US) 1985-05-07 — — US disclosed
US-4411820-A A GROUP 8 METAL COMPOUND, A HETEROAROMATIC NITROGEN COMPOUND, AND AN OXIDE OF URANIUM OR THORIUM GULF RESEARCH & DEVELOPMENT COMPANY (US) 1983-10-25 — — US disclosed
US-4357351-A HERBICIDES; INSECTICIDES; MOTHS STAUFFER CHEMICAL COMPANY (US) 1982-11-02 — — US disclosed
US-4331560-A NOBLE METAL COMPOUND AND A HETEROCYCLIC NITROGEN COMPOUND AS CATALYST SYSTEM GULF RESEARCH & DEVELOPMENT COMPANY (US) 1982-05-25 — — US disclosed
EP-0027111-A4 LEPIDOPTERICIDAL ISOTHIOUREA COMPOUNDS. STAUFFER CHEMICAL CO (US) 1982-04-08 — — EP disclosed
EP-0027111-A1 LEPIDOPTERICIDAL ISOTHIOUREA COMPOUNDS STAUFFER CHEMICAL COMPANY (US) 1981-04-22 — — EP disclosed
WO-1980002024-A1 LEPIDOPTERICIDAL ISOTHIOUREA COMPOUNDS STAUFFER CHEMICAL CO (US) 1980-10-02 — — WO disclosed
US-4070391-A Process for producing isocyanate from nitro compounds and carbon monoxide using rhodium oxide catalysts ETHYL CORPORATION (US) 1978-01-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230116771-A1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE HNMT, SLC10A1, SLC10A2 ALDH1A1 331/4885TSHR 1129/4885TDP1 1076/4885
US-11446389-B2 Maytansinoid derivatives, conjugates thereof, and methods of use HNMT, SLC10A1, SLC10A2 ALDH1A1 331/4885TSHR 1129/4885TDP1 1076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.