Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103505 | 0.91 | CYP3A4 (0.47) | ALDH1A1HIF1ATSHRLMNATDP1 | |
| SCHEMBL9339650 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HIF1ATSHRLMNATDP1 | |
| SCHEMBL8728355 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HIF1ATSHRLMNATDP1 | |
| SCHEMBL10184953 | 0.85 | ALDH1A1 (0.51) | ALDH1A1HIF1ATSHRLMNATDP1 | |
| SCHEMBL11232668 | 0.81 | GPR35 (0.50) | ALDH1A1HIF1ATSHRLMNATDP1 | |
| SCHEMBL1945604 | 0.79 | TXNRD1 (0.42) | ALDH1A1TSHRLMNATDP1HSD17B10 | |
| SCHEMBL1940462 | 0.79 | HSD17B10 (0.56) | ALDH1A1TSHRLMNATDP1HSD17B10 | |
| SCHEMBL374389 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TSHRLMNATDP1HSD17B10 | |
| SCHEMBL8862330 | 0.77 | TDP1 (0.52) | ALDH1A1HIF1ATSHRLMNATDP1 | |
| SCHEMBL697640 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HIF1ATSHRLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230116771-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. | 2023-04-13 | — | — | US | disclosed |
| EP-3408271-B1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMA (US) | 2023-01-11 | — | — | EP | disclosed |
| US-11446389-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| CN-108779127-B | Maytansinoid derivatives, conjugates thereof, and methods of use | 里珍纳龙药品有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114478801-A | Maytansinoid derivatives, conjugates thereof, and methods of use | 里珍纳龙药品有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20200121806-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. | 2020-04-23 | — | — | US | disclosed |
| US-10463749-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2019-11-05 | — | — | US | disclosed |
| EP-3408271-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | Regeneron Pharmaceuticals, Inc. (US) | 2018-12-05 | — | — | EP | disclosed |
| US-20180289834-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. | 2018-10-11 | — | — | US | disclosed |
| US-9950076-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | REGENERON PHARMACEUTICALS, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-5136868-A | HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF | FMC CORPORATION (US) | 1992-08-11 | — | — | US | disclosed |
| US-4868321-A | FOR HERBICIDES | FMC CORPORATION (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0252982-A4 | HERBICIDAL 1-ARYL-4-SUSTITUTTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. | FMC CORP (US) | 1988-08-17 | — | — | EP | disclosed |
| EP-0252982-A1 | HERBICIDAL 1-ARYL-4-SUSTITUTTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF | FMC Corporation (US) | 1988-01-20 | — | — | EP | disclosed |
| CN-86108880-A | 1-aryl-4 substituting group-1,4-dihydro-5H-tetrazolium-5-ketone and sulfur analogs weedicide thereof | — | 1987-07-22 | — | — | CN | disclosed |
| WO-1987003873-A1 | HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF | FMC CORPORATION (US) | 1987-07-02 | — | — | WO | disclosed |
| EP-0015110-B1 | ANTICOCCIDIAL COMPOSITION, CARBANILIDES AND METHOD OF PREPARING THEM | ELI LILLY AND COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4526997-A | Amino, nitro, fluoro substituted carbanilides | DOHERTY GEORGE O P O | 1985-07-02 | — | — | US | disclosed |
| US-4468380-A | Anticoccidial combinations comprising polyether antibiotics and carbanilides | ELI LILLY AND COMPANY (US) | 1984-08-28 | — | — | US | disclosed |
| EP-0015110-A2 | Anticoccidial composition, carbanilides and method of preparing them | ELI LILLY AND COMPANY (US) | 1980-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10463749-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885HIF1A 996/4885TSHR 1129/4885 |
| US-20230116771-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885HIF1A 996/4885TSHR 1129/4885 |
| US-20180289834-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885HIF1A 996/4885TSHR 1129/4885 |
| US-20200121806-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885HIF1A 996/4885TSHR 1129/4885 |
| US-11446389-B2 | Maytansinoid derivatives, conjugates thereof, and methods of use | HNMT, SLC10A1, SLC10A2 | ALDH1A1 331/4885HIF1A 996/4885TSHR 1129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.