Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771319 | 0.92 | MAPK1 (0.31) | — | |
| SCHEMBL27521035 | 0.73 | TSHR (0.30) | TSHR | |
| SCHEMBL2877333 | 0.72 | — | — | |
| SCHEMBL20448563 | 0.69 | SLC6A2 (0.33) | — | |
| SCHEMBL7107590 | 0.68 | TSHR (0.32) | TSHR | |
| SCHEMBL25673 | 0.68 | SLC6A4 (0.31) | — | |
| SCHEMBL1664714 | 0.67 | TSHR (0.47) | TSHR | |
| SCHEMBL7704778 | 0.67 | — | — | |
| SCHEMBL6346549 | 0.64 | TSHR (0.35) | TSHR | |
| SCHEMBL106532 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217060-B2 | Benzimidazole derivatives useful as TRP M8 receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-07-10 | — | — | US | disclosed |
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-11-18 | — | — | US | disclosed |
| US-20090234162-A1 | Radioactive Halogen-Labeled Phenyloxyaniline Derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1854781-A1 | RADIOACTIVE HALOGEN-LABELED PHENYLOXYANILINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2007-11-14 | — | — | EP | disclosed |
| US-6476056-B2 | ANTIINFLAMMATORY AGENTS, PSYCHOLOGICAL DISORDERS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1004573-B1 | ARYLOXYANILINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-10-30 | — | — | EP | disclosed |
| US-20020147191-A1 | Aryloxyaniline derivatives | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-10-10 | — | — | US | disclosed |
| US-6333358-B1 | AMIDE DERIVATIVES OF ANILINE AS ANTIDEPRESSANTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1004573-A1 | ARYLOXYANILINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147191-A1 | Aryloxyaniline derivatives | FPR2, ARG2, CYP11B2 | TSHR 2443/4885 |
| US-20100292276-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS | TRPM8, TRPV1, TRPA1 | TSHR 2835/4885 |
| US-20090234162-A1 | Radioactive Halogen-Labeled Phenyloxyaniline Derivatives | TSPO, PBRM1, PSEN1 | TSHR 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.