Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.72 |
| ▸ | NOS1 | P29475 | 2/20 | 0.72 |
| ▸ | NOS2 | P35228 | 2/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | PLAU | P00749 | 6/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 7/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 6/20 | 0.54 |
| ▸ | SLC22A3 | O75751 | 6/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27685590 | 0.81 | ADRA2A (0.71) | NOS3NOS1ADRA2AADRA2BADRA2C | |
| SCHEMBL16562419 | 0.79 | PLAU (1.00) | ADRA2AADRA2BADRA2CPOLBPLAU | |
| SCHEMBL25147342 | 0.77 | PLAU (0.73) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL2492526 | 0.77 | ADRA2A (0.65) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL22623279 | 0.74 | PLAU (0.62) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL27981476 | 0.74 | NOS1 (0.62) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL1738380 | 0.74 | POLB (0.82) | ADRA2AADRA2BADRA2CPOLBPLAU | |
| SCHEMBL2202972 | 0.74 | NOS3 (0.56) | NOS3NOS1NOS2CA12CA1 | |
| SCHEMBL2202977 | 0.74 | NOS3 (0.56) | NOS3NOS1NOS2CA12CA1 | |
| SCHEMBL5447808 | 0.73 | PLAU (0.66) | NOS3NOS1NOS2ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103739589-A | N- (2, 3-dihydrobenzo [ b ] thiopyran-4-imino) -N' - (4-methylphenyl) guanidine derivative and application thereof | UNIV SHENYANG PHARMACEUTICAL | 2014-04-23 | — | — | CN | disclosed |
| US-8476306-B2 | Urokinase inhibitors, production and use thereof | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-07-02 | — | — | US | disclosed |
| US-20110065799-A1 | UROKINASE INHIBITORS, PRODUCTION AND USE THEREOF | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-03-17 | — | — | US | disclosed |
| US-7838560-B2 | for the therapy, prophylaxis and diagnosis of a tumor; benzylsulfonyl-D-Ser-Glu-4-amidinobenzylamidexTFA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-20080221082-A1 | Ligands of Integrin Receptors | ABBOTT GMBH & CO. KG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-7105508-B1 | Integrin receptors antagonists | ABBOTT GMBH & CO. KG (DE) | 2006-09-12 | — | — | US | disclosed |
| US-20050176993-A1 | Urokinase inhibitors, production and use thereof | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2005-08-11 | — | — | US | disclosed |
| EP-1286673-B8 | LIGANDS OF INTEGRIN RECEPTORS | ABBOTT GMBH & CO KG (DE) | 2005-07-20 | — | — | EP | disclosed |
| EP-1286673-B1 | LIGANDS OF INTEGRIN RECEPTORS | BASF AG (DE) | 2005-05-25 | — | — | EP | disclosed |
| US-6831196-B2 | Such as benzylsulfonyl-D-Ser-Gly-4-amidinobenzylamide, HCl salt; for treatment of malign tumors/metastatic spread | CURACYTE AG (DE) | 2004-12-14 | — | — | US | disclosed |
| US-20030166576-A1 | Urokinase inhibitors | WILEX AG (DE) | 2003-09-04 | — | — | US | disclosed |
| EP-1286673-A2 | LIGANDS OF INTEGRIN RECEPTORS | Basf Aktiengesellschaft (DE) | 2003-03-05 | — | — | EP | disclosed |
| CN-1374960-A | novel integrin receptor antagonists | BASF AG (DE) | 2002-10-16 | — | — | CN | disclosed |
| EP-1202988-A2 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001093840-A2 | LIGANDS OF INTEGRIN RECEPTORS | BASF AG (DE) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001010847-A2 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166576-A1 | Urokinase inhibitors | PLAU, PLAUR, PLAT | NOS3 3293/4885NOS1 3104/4885NOS2 3063/4885 |
| US-20050176993-A1 | Urokinase inhibitors, production and use thereof | PLAU, PLAUR, SERPINE1 | NOS3 2729/4885NOS1 2712/4885NOS2 2779/4885 |
| US-20110065799-A1 | UROKINASE INHIBITORS, PRODUCTION AND USE THEREOF | PLAU, PLAUR, SERPINE1 | NOS3 2729/4885NOS1 2712/4885NOS2 2779/4885 |
| US-20080221082-A1 | Ligands of Integrin Receptors | ITGB3, ITGAV, ITGA2B | NOS3 3942/4885NOS1 4672/4885NOS2 4593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.