SCHEMBL375669

SCHEMBL375669

Cc1ccc(Br)cc1[N+](=O)[O-]

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.60
ALDH1A1 P00352 4/20 0.60
CYP3A4 P08684 2/20 0.60
RECQL P46063 1/20 0.60
HSD17B10 Q99714 1/20 0.52
CYP1A2 P05177 1/20 0.50
MAPT P10636 2/20 0.49
GAA P10253 1/20 0.49
S100A4 P26447 1/20 0.49
TRPV1 Q8NER1 1/20 0.49
CES2 O00748 1/20 0.49
CES1 P23141 1/20 0.49
TDP1 Q9NUW8 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
MEN1 O00255 1/20 0.45
NPC1 O15118 1/20 0.45
LMNA P02545 1/20 0.45
MAPK1 P28482 1/20 0.45
RAB9A P51151 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30955249 1.00 TSHR (0.60) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL27875768 0.98 TSHR (0.58) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL1459853 0.83 MAPT (0.56) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL31005993 0.83 MAPT (0.56) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL1561802 0.80 TSHR (0.56) TSHRALDH1A1CYP3A4CYP1A2MAPT
SCHEMBL8147367 0.80 TSHR (0.43) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL8155350 0.80 TSHR (0.43) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL29613904 0.78 TSHR (0.72) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL7190826 0.78 TSHR (0.64) TSHRALDH1A1CYP3A4RECQLHSD17B10
SCHEMBL171914 0.78 TSHR (0.72) TSHRALDH1A1CYP3A4RECQLHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 744 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117466759-A Preparation method of 2-amino-4-bromo-5-chlorobenzoic acid 阜新清稷升科技有限公司 2024-01-30 CN claimed
EP-3692101-B1 BRILLIANT BLUE (BBG) DYE DERIVATIVES AND STAINING COMPOSITIONS COMPRISING THE SAME FOR SELECTIVELY STAINING BIOLOGICAL SUBSTRATES ALFA INSTR S R L (IT) 2022-01-12 EP claimed
EP-3692101-A1 BRILLIANT BLUE (BBG) DYE DERIVATIVES AND STAINING COMPOSITIONS COMPRISING THE SAME FOR SELECTIVELY STAINING BIOLOGICAL SUBSTRATES Alfa Instruments S.r.l. (IT) 2020-08-12 EP claimed
WO-2019068935-A1 BRILLIANT BLUE (BBG) DYE DERIVATIVES AND STAINING COMPOSITIONS COMPRISING THE SAME FOR SELECTIVELY STAINING BIOLOGICAL SUBSTRATES ALFA INSTRUMENTS S.R.L. (IT) 2019-04-11 WO claimed
EP-2940009-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VentiRx Pharmaceuticals, Inc. (US) 2015-11-04 EP claimed
EP-2358683-B1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS INC (US) 2015-04-01 EP claimed
US-8314090-B2 Methods of synthesis of benzazepine derivatives VENTIRX PHARMACEUTICALS, INC. (US) 2012-11-20 US claimed
EP-2358683-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES Ventirx Pharmaceuticals, Inc. (US) 2011-08-24 EP claimed
US-20100216989-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-08-26 US claimed
WO-2010054215-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-05-14 WO claimed
CN-1047377-C Preparation method of 2-fluor-4-bromotoluene, 2-fluor-4-bromo benzyl bromide and its 2-fluor-4-bromo benzyl bromide FUXIN SPECIAL CHEMICALS CO LTD (CN) 1999-12-15 CN claimed
CN-1157812-A Preparation method of 2-fluor-4-bromotoluene, 2-fluor-4-bromo benzyl bromide and its 2-fluor-4-bromo benzyl bromide FUXIN SPECIAL CHEMICALS CO LTD (CN) 1997-08-27 CN claimed
US-12570610-B2 Macromolecule-supported aminobenzazepine compounds BOLT BIOTHERAPEUTICS, INC. (US) 2026-03-10 US disclosed
US-20260049080-A1 WILD TYPE KIT INHIBITORS BLUEPRINT MEDICINES CORP (US) 2026-02-19 US disclosed
US-12448379-B2 Wild type kit inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2025-10-21 US disclosed
US-20250304573-A1 LYSERGIC ACID DERIVATIVES AND METHODS UNIV FLORIDA STATE RES FOUND INC (US) 2025-10-02 US disclosed
US-4126626-A DYES, POLYESTERS CIBA-GEIGY CORPORATION (US) 1978-11-21 US disclosed
US-4020107-A ACIDIC PHOSPHORUS COMPOUND DEHALOGENATION INHIBITOR E. I. DU PONT DE NEMOURS AND CO. (US) 1977-04-26 US disclosed
US-3996052-A Phototropic compounds as acid catalyst in photopolymerizing process AMERICAN CAN COMPANY (US) 1976-12-07 US disclosed
US-3949143-A Epoxy resin coatings cured with phototropic aromatic nitro compounds AMERICAN CAN COMPANY (US) 1976-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100216989-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES MAOB, GABBR1, HNMT TSHR 3576/4885ALDH1A1 536/4885CYP3A4 17/4885
US-20260049080-A1 WILD TYPE KIT INHIBITORS KIT, CSNK1A1, CSNK1A1L TSHR 3143/4885ALDH1A1 741/4885CYP3A4 2266/4885
US-12448379-B2 Wild type kit inhibitors KIT, TNK1, TNNI3K TSHR 4256/4885ALDH1A1 1830/4885CYP3A4 4552/4885
US-20250304573-A1 LYSERGIC ACID DERIVATIVES AND METHODS AADAT, HTR3A, HNMT TSHR 1456/4885ALDH1A1 2036/4885CYP3A4 1815/4885
US-12570610-B2 Macromolecule-supported aminobenzazepine compounds BCL6, CLTB, MET TSHR 1278/4885ALDH1A1 2418/4885CYP3A4 1879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.