Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903809 | 0.81 | SIGMAR1 (0.32) | CRHR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL1773270 | 0.77 | ADRA2A (0.36) | HTR2AALDH1A1 | |
| SCHEMBL1773267 | 0.77 | ADRA2A (0.36) | HTR2AALDH1A1 | |
| SCHEMBL27309973 | 0.77 | SIGMAR1 (0.47) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| Bromide SCHEMBL28710071 | 0.75 | SIGMAR1 (0.46) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| Bromide SCHEMBL28694187 | 0.75 | SIGMAR1 (0.46) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| Bromide SCHEMBL28712119 | 0.75 | SIGMAR1 (0.46) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| Bromide SCHEMBL28935313 | 0.75 | SIGMAR1 (0.46) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL3635488 | 0.75 | SIGMAR1 (0.46) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL2530767 | 0.75 | SIGMAR1 (0.50) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7847117-B2 | Process for preparing alkyl(methoxymethyl)trimethylsilanylmethylamines | WACKER CHEMIE AG (DE) | 2010-12-07 | — | — | US | disclosed |
| US-20090036700-A1 | Process For Preparing Alkyl(Methoxymethyl)Trimethylsilanylmethylamines | WACKER CHEMIE AG (DE) | 2009-02-05 | — | — | US | disclosed |
| US-7479504-B2 | Edg receptor agonists | MERCK & CO., INC. (US) | 2009-01-20 | — | — | US | disclosed |
| EP-1470137-A4 | EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20050070506-A1 | Selective s1p1/edg1 receptor agonists | DOHERTY GEORGE A (US) | 2005-03-31 | — | — | US | disclosed |
| US-20050033055-A1 | Edg receptor agonists | MERCK SHARP & DOHME CORP. | 2005-02-10 | — | — | US | disclosed |
| EP-1469863-A2 | SELECTIVE S1P1/EDG1 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2004-10-27 | — | — | EP | disclosed |
| EP-1470137-A1 | EDG RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2004-10-27 | — | — | EP | disclosed |
| US-20040058894-A1 | Selective S1P1/Edg1 receptor agonists | DOHERTY GEORGE A (US) | 2004-03-25 | — | — | US | disclosed |
| WO-2003062252-A1 | EDG RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| WO-2003061567-A2 | SELECTIVE S1P1/EDG1 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070506-A1 | Selective s1p1/edg1 receptor agonists | S1PR1, S1PR3, S1PR5 | CRHR1 204/4885OPRM1 3242/4885OPRD1 1927/4885 |
| US-20040058894-A1 | Selective S1P1/Edg1 receptor agonists | S1PR1, S1PR3, S1PR2 | CRHR1 279/4885OPRM1 2724/4885OPRD1 1729/4885 |
| US-20090036700-A1 | Process For Preparing Alkyl(Methoxymethyl)Trimethylsilanylmethylamines | PNMT, TET2, HNMT | CRHR1 4376/4885OPRM1 180/4885OPRD1 1822/4885 |
| US-20050033055-A1 | Edg receptor agonists | EDNRA, EDNRB, GPR65 | CRHR1 169/4885OPRM1 305/4885OPRD1 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.