Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655880 | 0.82 | MMP9 (0.55) | TP53ALDH1A1KMT2ALMNANPSR1 | |
| SCHEMBL3652452 | 0.72 | TRPM8 (0.42) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL11709815 | 0.72 | TRPM8 (0.57) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL9234594 | 0.71 | TRPM8 (0.45) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL9212885 | 0.70 | TP53 (0.64) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL23798915 | 0.69 | TRPM8 (0.45) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL11618036 | 0.69 | ALDH1A1 (0.68) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL9212188 | 0.69 | TP53 (0.67) | TP53ALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL15333351 | 0.69 | MTNR1A (0.38) | MEN1KMT2ALMNAMTNR1AMTNR1B | |
| SCHEMBL30957369 | 0.67 | TP53 (0.61) | TP53ALDH1A1TRPM8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311749-A1 | 4-BENZOYL-1-SUBSTITUTED-PIPERAZIN-2-ONE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311749-A1 | 4-BENZOYL-1-SUBSTITUTED-PIPERAZIN-2-ONE DERIVATIVES AS P2X7 MODULATORS | P2RX7, P2RX3, P2RX2 | TP53 3437/4885ALDH1A1 3763/4885TRPM8 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.