Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | CCR8 | P51685 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL637824 | 0.84 | KDM4E (0.47) | NPC1TSHRKDM4ECA12CA9 | |
| SCHEMBL10499384 | 0.72 | CTSD (0.49) | KMT2ANPC1TP53SMN1; SMN2TSHR | |
| Dipyridyl SCHEMBL28172048 | 0.68 | KDM4E (0.70) | NPC1TP53SMN1; SMN2TSHRRAB9A | |
| Dipyridyl SCHEMBL10393998 | 0.68 | KDM4E (0.70) | NPC1TP53SMN1; SMN2TSHRRAB9A | |
| Dipyridyl SCHEMBL9872270 | 0.66 | KDM4E (0.67) | NPC1TP53SMN1; SMN2RAB9AMETAP1 | |
| SCHEMBL21534086 | 0.63 | KMT2A (0.56) | KMT2ANPC1TP53SMN1; SMN2RAB9A | |
| SCHEMBL9611671 | 0.63 | KMT2A (0.66) | BACE1KMT2ANPC1TP53SMN1; SMN2 | |
| Dimethyl Sulfoxide SCHEMBL28835221 | 0.63 | GRM5 (0.42) | KMT2ANPC1SMN1; SMN2RAB9AMETAP1 | |
| SCHEMBL23131225 | 0.62 | NPSR1 (0.39) | BACE1KMT2ANPC1RAB9APOLB | |
| Dipyridyl SCHEMBL28268549 | 0.61 | KDM4E (0.82) | NPC1TP53SMN1; SMN2TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317689-A1 | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety | ALEVIUM PHARMACEUTICALS, INC. | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317689-A1 | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety | ABCB11, ATP6AP1, CYP4B1 | BACE1 4079/4885KMT2A 1889/4885NPC1 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.