Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767458 | 1.00 | TSHR (0.32) | TSHR | |
| SCHEMBL5880313 | 1.00 | TSHR (0.32) | TSHR | |
| Hydrochloric Acid SCHEMBL5880365 | 0.98 | TSHR (0.31) | TSHR | |
| Trimethylammonium SCHEMBL27325918 | 0.94 | — | — | |
| SCHEMBL3767653 | 0.83 | — | — | |
| SCHEMBL14257118 | 0.83 | — | — | |
| SCHEMBL3767656 | 0.83 | — | — | |
| SCHEMBL6133165 | 0.81 | TSHR (0.31) | TSHR | |
| SCHEMBL3549809 | 0.81 | TSHR (0.31) | TSHR | |
| SCHEMBL3549805 | 0.81 | TSHR (0.31) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020028931-A1 | Ceftiofur, its intermediate and a process for the preparation of the same | AUROBINDO PHARMA LIMITED (IN) | 2002-03-07 | — | — | US | claimed |
| EP-0842937-A2 | Process for the preparation of the cephalosporin derivatives cefotaxime and ceftriaxone | Hichem Pharma S.p.A. (IT) | 1998-05-20 | — | — | EP | claimed |
| US-4959495-A | Process for the preparation of intermediates used to produce aminothiazoloximino cephalosporins | AMERICAN CYANAMID COMPANY (US) | 1990-09-25 | — | — | US | claimed |
| EP-0257275-A2 | Cephalosporin and penicillin derivatives | AMERICAN CYANAMID COMPANY (US) | 1988-03-02 | — | — | EP | claimed |
| US-8212024-B2 | crystallizing Ceftiofur sodium directly from the reaction mass; obviates the use of amine, sodium salt of weak acid like sodium 2-ethylhexonate and membrane filtration in Ceftiofur sodium synthesis | ORCHID CHEMICALS & PHARMACEUTICALS LTD. (IN) | 2012-07-03 | — | — | US | disclosed |
| US-7847093-B2 | Processes for the preparations of cefepime | SANDOZ AG (CH) | 2010-12-07 | — | — | US | disclosed |
| EP-2218723-A2 | Processes for the preparations of cefepime | Sandoz AG (CH) | 2010-08-18 | — | — | EP | disclosed |
| US-7479556-B2 | Process for producing Cefepime and cephalosporin analogues | ACS DOBFAR S.P.A. (IT) | 2009-01-20 | — | — | US | disclosed |
| US-7470786-B2 | Method for manufacture of ceftriaxone sodium | LUPIN LIMITED (IN) | 2008-12-30 | — | — | US | disclosed |
| US-7452990-B2 | 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate; cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, etc | LUPIN LIMITED (IN) | 2008-11-18 | — | — | US | disclosed |
| US-20080221076-A1 | Crystalline Sodium Salt of Cephalosporin Antibiotic | ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2008-09-11 | — | — | US | disclosed |
| US-20080200670-A1 | METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM | LUPIN LIMITED (RESEARCH PARK) (IN) | 2008-08-21 | — | — | US | disclosed |
| US-4927964-A | Method for production of 2-oxyimino-3-oxobutyric acids | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-05-22 | — | — | US | disclosed |
| EP-0325183-A2 | Method for the production of 2-oxyimino-3-oxobutyric acids | Takeda Chemical Industries, Ltd. (JP) | 1989-07-26 | — | — | EP | disclosed |
| EP-0324418-A2 | Method for production of t-butyl- 3-oxobutyrates and their use | Takeda Chemical Industries, Ltd. (JP) | 1989-07-19 | — | — | EP | disclosed |
| US-4845257-A | 4-halogeno-2-oxyimino-3-oxobutyric acids and derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0257275-A2 | Cephalosporin and penicillin derivatives | AMERICAN CYANAMID COMPANY (US) | 1988-03-02 | — | — | EP | disclosed |
| EP-0246603-A2 | 4-Halogeno-2-Oxyimino-3-Oxobutyric acids | Takeda Chemical Industries, Ltd. (JP) | 1987-11-25 | — | — | EP | disclosed |
| EP-0223246-A2 | New cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-05-27 | — | — | EP | disclosed |
| US-4166115-A | BACTERICIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028931-A1 | Ceftiofur, its intermediate and a process for the preparation of the same | BLVRB, CBR1, BTD | TSHR 510/4885 |
| US-20080200670-A1 | METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM | CHAT, TREH, MRPL21 | TSHR 3037/4885 |
| US-20080221076-A1 | Crystalline Sodium Salt of Cephalosporin Antibiotic | SLC5A1, SLC5A2, SHARPIN | TSHR 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.