Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL989787 | 1.00 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28068962 | 0.97 | HIF1A (0.40) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Aziridine SCHEMBL476461 | 0.96 | — | — | |
| Aziridine SCHEMBL6276086 | 0.96 | TSHR (0.36) | HIF1AMAPTPDE4AKDRHSD17B10 | |
| SCHEMBL28142052 | 0.91 | CXCR4 (0.53) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL28021595 | 0.88 | CXCR4 (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL157612 | 0.87 | — | — | |
| Piperazine SCHEMBL1132834 | 0.85 | TSHR (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL14815556 | 0.84 | ALDH1A1 (0.44) | MAPTCXCR4SMN1; SMN2HSD17B10ATM | |
| Pyrrolidine SCHEMBL6930404 | 0.84 | ALDH1A1 (0.44) | MAPTCXCR4SMN1; SMN2HSD17B10ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240173292-A1 | COMPOUNDS THAT SYNERGIZE WITH COPPER TO KILL STREPTOCOCCUS PNEUMONIAE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-05-30 | — | — | US | disclosed |
| EP-1554241-B1 | S-(ALPHA,ALPHA'-DISUBSTITUTED-ALPHA\"-ACETIC ACID) SUBSTITUTED DITHIOCARBONATE DERIVATIVES FOR CONTROLLED RADICAL POLYMERISATIONS, PROCESS AND POLYMERS MADE THEREFROM | LUBRIZOL ADVANCED MAT INC (US) | 2015-03-18 | — | — | EP | disclosed |
| US-7851582-B2 | S-(α, α′-disubstituted-α″-acetic acid)—substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-7498456-B2 | S-(α, α′-disubstituted-α″-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerization, process and polymers made therefrom | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-20080214773-A1 | S-(Alpha, Alpha'-Disubstituted-Alpha\"-Acetic Acid) - Substituted Dithiocarbonate Derivatives For Controlled Radical Polymerizations, Process and Polymers Made Therefrom | LAI JOHN TA-YUAN | 2008-09-04 | — | — | US | disclosed |
| US-7335788-B2 | S-(α, α′-disubstituted-α″-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-20070167571-A1 | S-(Alpha, Alpha'-Disubstituted-Alpha\"-Acetic Acid) Substituted Dithiocarbonate Derivatives for Controlled Radical Polymerizations, Process and Polymers Made Therefrom | LUBRIZOL ADVANCED MATERIALS, INC. | 2007-07-19 | — | — | US | disclosed |
| US-7205368-B2 | S-(α, α′-disubstituted-α′ ′-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | NOVEON, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2005080326-A1 | TOUGHENED VINYL ESTER RESINS | NOVEON IP HOLDINGS CORP. (US) | 2005-09-01 | — | — | WO | disclosed |
| EP-1554241-A1 | S-(ALPHA,ALPHA'-DISUBSTITUTED-ALPHA\"-ACETIC ACID) SUBSTITUTED DITHIOCARBONATE DERIVATIVES FOR CONTROLLED RADICAL POLYMERISATIONS, PROCESS AND POLYMERS MADE THEREFROM | Noveon IP Holdings Corp. (US) | 2005-07-20 | — | — | EP | disclosed |
| US-20050014910-A1 | Toughened vinyl ester resins | NOVEON, INC. | 2005-01-20 | — | — | US | disclosed |
| WO-2004037780-A1 | S-(a, a’ -DISUBSTITUTED-a” -ACETIC ACID) SUBSTITUTED DITHIOCARBONATE DERIVATIVES FOR CONTROLLED RADICAL POLYMERIZATIONS, PROCESS AND POLYMERS MADE THEREFROM | NOVEON IP HOLDINGS CORP. (US) | 2004-05-06 | — | — | WO | disclosed |
| US-20040073056-A1 | S-(alpha, alpha'-disubstituted-alpha\"-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | LUBRIZOL ADVANCED MATERIALS, INC. | 2004-04-15 | — | — | US | disclosed |
| US-20030120101-A1 | S-(alpha, alpha'-disubstituted-alpha' '-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | LUBRIZOL ADVANCED MATERIALS, INC. | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030120101-A1 | S-(alpha, alpha'-disubstituted-alpha' '-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | TST, SRM, ACMSD | HIF1A 2873/4885MAPT 1508/4885PDE4A 4200/4885 |
| US-20080214773-A1 | S-(Alpha, Alpha'-Disubstituted-Alpha\"-Acetic Acid) - Substituted Dithiocarbonate Derivatives For Controlled Radical Polymerizations, Process and Polymers Made Therefrom | TST, ACMSD, ETFA | HIF1A 2512/4885MAPT 1485/4885PDE4A 4040/4885 |
| US-20070167571-A1 | S-(Alpha, Alpha'-Disubstituted-Alpha\"-Acetic Acid) Substituted Dithiocarbonate Derivatives for Controlled Radical Polymerizations, Process and Polymers Made Therefrom | TST, ACMSD, SRM | HIF1A 2735/4885MAPT 1573/4885PDE4A 4091/4885 |
| US-20240173292-A1 | COMPOUNDS THAT SYNERGIZE WITH COPPER TO KILL STREPTOCOCCUS PNEUMONIAE | CAPG, CD47, DSTN | HIF1A 2855/4885MAPT 1027/4885PDE4A 3198/4885 |
| US-20040073056-A1 | S-(alpha, alpha'-disubstituted-alpha\"-acetic acid) substituted dithiocarbonate derivatives for controlled radical polymerizations, process and polymers made therefrom | TST, ACMSD, SRM | HIF1A 2735/4885MAPT 1573/4885PDE4A 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.