Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL3767537 | 1.00 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28068962 | 0.97 | HIF1A (0.40) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Aziridine SCHEMBL476461 | 0.96 | — | — | |
| Aziridine SCHEMBL6276086 | 0.96 | TSHR (0.36) | HIF1AMAPTPDE4AKDRHSD17B10 | |
| SCHEMBL28142052 | 0.91 | CXCR4 (0.53) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL28021595 | 0.88 | CXCR4 (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL157612 | 0.87 | — | — | |
| Piperazine SCHEMBL1132834 | 0.85 | TSHR (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL14815556 | 0.84 | ALDH1A1 (0.44) | MAPTCXCR4SMN1; SMN2HSD17B10ATM | |
| Pyrrolidine SCHEMBL6930404 | 0.84 | ALDH1A1 (0.44) | MAPTCXCR4SMN1; SMN2HSD17B10ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4660332-A1 | PROCESS FOR SEPARATING RARE-EARTH METALS IN ADMIXTURE IN AQUEOUS SOLUTION | SNF SA (FR) | 2025-12-10 | — | — | EP | claimed |
| US-20250369075-A1 | PROCESS FOR SEPARATING RARE-EARTH METALS IN ADMIXTURE IN AQUEOUS SOLUTION | SNF SA (FR) | 2025-12-04 | — | — | US | claimed |
| EP-4294576-B1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | TESSENDERLO KERLEY INC (US) | 2024-12-25 | — | — | EP | claimed |
| US-20240149277-A1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | TESSENDERLO KERLEY, INC. (US) | 2024-05-09 | — | — | US | claimed |
| CN-114534158-A | Composite stabilizer with waste incineration fly ash heavy metal stability | 天津壹鸣环境科技股份有限公司 | 2022-05-27 | — | — | CN | claimed |
| CN-105143202-B | Dithiocarboxylic acid esters having spermicidal activity and process for their preparation | 科学与工业研究委员会 | 2018-08-14 | — | — | CN | claimed |
| CN-105143202-A | Dithiocarboxylic acid esters having spermicidal activity and process for their preparation | COUNCIL SCIENT IND RES | 2015-12-09 | — | — | CN | claimed |
| CN-102335494-B | Heavy metal stabilizing treatment method for dust containing heavy metals | KURITA WATER IND LTD | 2015-03-04 | — | — | CN | claimed |
| CN-103819026-A | Resource utilization method of high-concentration ammonia nitrogen waste liquid | HUIZHOU TCL ENVIRONMENTAL TECHNOLOGY CO LTD | 2014-05-28 | — | — | CN | claimed |
| CN-103456885-A | Uses of dithiocarbamate compounds | SONY CORP | 2013-12-18 | — | — | CN | claimed |
| US-20130264545-A2 | USES OF DITHIOCARBAMATE COMPOUNDS | SONY CORPORATION (JP) | 2013-10-10 | — | — | US | claimed |
| CN-102335494-A | Heavy metal stabilizing treatment method for dust containing heavy metals | KURITA WATER IND LTD | 2012-02-01 | — | — | CN | claimed |
| US-20110031481-A1 | USES OF DITHIOCARBAMATE COMPOUNDS | SONY CORPORATION (JP) | 2011-02-10 | — | — | US | claimed |
| CN-101964396-A | Use of dithiocarbamate compounds | SONY CORP | 2011-02-02 | — | — | CN | claimed |
| EP-2278636-A1 | Uses of dithiocarbamate compounds | Sony Corporation (JP) | 2011-01-26 | — | — | EP | claimed |
| EP-4660332-A1 | PROCESS FOR SEPARATING RARE-EARTH METALS IN ADMIXTURE IN AQUEOUS SOLUTION | SNF SA (FR) | 2025-12-10 | — | — | EP | disclosed |
| US-20250369075-A1 | PROCESS FOR SEPARATING RARE-EARTH METALS IN ADMIXTURE IN AQUEOUS SOLUTION | SNF SA (FR) | 2025-12-04 | — | — | US | disclosed |
| JP-2006000829-A | METHOD FOR DETERMINING REQUIRED AMOUNT OF HEAVY METAL TREATING AGENT AND APPARATUS USING THE SAME | TOSOH CORP | 2006-01-05 | — | — | JP | disclosed |
| US-20040176504-A1 | Additive compound for curing halogenated polymers | VANDERBILT CHEMICALS, LLC | 2004-09-09 | — | — | US | disclosed |
| US-4133775-A | Dichroic light polarizers stained with metal chelates | POLAROID CORPORATION (US) | 1979-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176504-A1 | Additive compound for curing halogenated polymers | XRCC5, NAA15, TERT | HIF1A 3137/4885MAPT 3894/4885PDE4A 2910/4885 |
| US-20130264545-A2 | USES OF DITHIOCARBAMATE COMPOUNDS | DDT, TST, VDAC2 | HIF1A 4811/4885MAPT 2350/4885PDE4A 3842/4885 |
| US-20110031481-A1 | USES OF DITHIOCARBAMATE COMPOUNDS | DDT, TST, VDAC2 | HIF1A 4811/4885MAPT 2350/4885PDE4A 3842/4885 |
| US-20240149277-A1 | DITHIOCARBAMATE DEPRESSANTS, METHODS AND USES THEREOF IN FROTH FLOTATION MINERAL SEPARATION | ACMSD, AP2A1, CA3 | HIF1A 765/4885MAPT 503/4885PDE4A 3585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.