Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Levulinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.88 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.55 |
| ▸ | KDM5C | P41229 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | KDM6B | O15054 | 3/20 | 0.55 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levulinic Acid SCHEMBL1683268 | 1.00 | LMNA (0.88) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL28278899 | 0.97 | LMNA (0.93) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL27945383 | 0.97 | — | — | |
| Levulinic Acid SCHEMBL12971398 | 0.97 | — | — | |
| Levulinic Acid SCHEMBL28938454 | 0.94 | LMNA (0.88) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL8418930 | 0.94 | LMNA (0.88) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL30530258 | 0.94 | — | — | |
| Levulinic Acid SCHEMBL27931545 | 0.94 | LMNA (1.00) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL113572 | 0.94 | LMNA (1.00) | LMNASLC15A2ALDH1A1EGLN1ALKBH5 | |
| Levulinic Acid SCHEMBL20868 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408317-B1 | DIETARY SUPPLEMENT | GREENTEAM HOLDINGS LTD (GB) | 2017-10-04 | — | — | EP | claimed |
| EP-2996495-A1 | CALCIUM SUPPLEMENT | Calinnova Ltd (GB) | 2016-03-23 | — | — | EP | claimed |
| US-20150201650-A1 | DIETARY SUPPLEMENT | Greenteam Holdings Limited (GB) | 2015-07-23 | — | — | US | claimed |
| WO-2014177876-A1 | CALCIUM SUPPLEMENT | CALINNOVA LTD (GB) | 2014-11-06 | — | — | WO | claimed |
| US-20120121754-A1 | Dietary Supplement | CALLINOVA LTD (GB) | 2012-05-17 | — | — | US | claimed |
| EP-2408317-A1 | DIETARY SUPPLEMENT | Calinnova Ltd (GB) | 2012-01-25 | — | — | EP | claimed |
| WO-2010106351-A1 | DIETARY SUPPLEMENT | VETAFARM EUROPE LTD (GB) | 2010-09-23 | — | — | WO | claimed |
| EP-2019584-B1 | COMPOSITE PRODUCT FOR DIFFUSING AN ACTIVE AGENT | SPADO S A (FR) | 2009-12-02 | — | — | EP | claimed |
| EP-2408317-B1 | DIETARY SUPPLEMENT | GREENTEAM HOLDINGS LTD (GB) | 2017-10-04 | — | — | EP | disclosed |
| EP-2996495-A1 | CALCIUM SUPPLEMENT | Calinnova Ltd (GB) | 2016-03-23 | — | — | EP | disclosed |
| US-20150201650-A1 | DIETARY SUPPLEMENT | Greenteam Holdings Limited (GB) | 2015-07-23 | — | — | US | disclosed |
| CN-104447285-A | Novel crystal form of calcium levulinate monohydrate | GUANGZHOU BAIYUNSHAN TIANXIN PHARMACEUTICAL CO LTD | 2015-03-25 | — | — | CN | disclosed |
| WO-2014177876-A1 | CALCIUM SUPPLEMENT | CALINNOVA LTD (GB) | 2014-11-06 | — | — | WO | disclosed |
| US-20120121754-A1 | Dietary Supplement | CALLINOVA LTD (GB) | 2012-05-17 | — | — | US | disclosed |
| EP-2408317-A1 | DIETARY SUPPLEMENT | Calinnova Ltd (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106351-A1 | DIETARY SUPPLEMENT | VETAFARM EUROPE LTD (GB) | 2010-09-23 | — | — | WO | disclosed |