SCHEMBL377313

SCHEMBL377313

O=C(O)CN(CC(=O)O)Cc1cccc(CN(CC(=O)O)CC(=O)O)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.41
TDP1 Q9NUW8 5/20 0.41
ALOX15 P16050 3/20 0.41
TSHR P16473 3/20 0.41
CYP2C19 P33261 2/20 0.41
HIF1A Q16665 1/20 0.41
EYA2 O00167 1/20 0.41
APP P05067 1/20 0.41
ACE P12821 1/20 0.41
PGK1 P00558 1/20 0.41
PGK2 P07205 1/20 0.41
KDM4E B2RXH2 2/20 0.39
LMNA P02545 1/20 0.39
CHRM2 P08172 1/20 0.39
ADRA2A P08913 1/20 0.39
DRD1 P21728 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
ADRA1A P35348 1/20 0.39
DRD3 P35462 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14496261 0.91 TDP1 (0.43) NPSR1TDP1ALOX15TSHRCYP2C19
SCHEMBL15483848 0.91 TDP1 (0.46) NPSR1TDP1ALOX15TSHRCYP2C19
SCHEMBL8765490 0.90 TDP1 (0.38) NPSR1TDP1ALOX15TSHRCYP2C19
SCHEMBL6161950 0.89 TDP1 (0.37) NPSR1TDP1ALOX15TSHRCYP2C19
SCHEMBL23568184 0.88 KDM4E (0.50) TDP1ALOX15TSHRKDM4ELMNA
SCHEMBL15483569 0.87 SMN1; SMN2 (0.37) NPSR1TDP1ALOX15TSHRCYP2C19
SCHEMBL29892650 0.83 KDM4E (0.48) TDP1ALOX15TSHRCYP2C19EYA2
SCHEMBL2349945 0.83 KDM4E (0.48) TDP1ALOX15TSHRCYP2C19EYA2
SCHEMBL14496263 0.83 ALOX15 (0.40) TDP1ALOX15TSHRCYP2C19HIF1A
SCHEMBL15865623 0.82 KDM4E (0.47) TDP1ALOX15TSHRCYP2C19EYA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408930-B1 BIOTINIDASE ASSAY WALLAC OY (FI) 2015-05-06 EP claimed
US-8597903-B2 Biotinidase assay WALLAC OY (FI) 2013-12-03 US claimed
US-20120045784-A1 BIOTINIDASE ASSAY Joachim Ngiamas trustee for Joachim Ngiam Trust Fund ABN 2012-02-23 US claimed
EP-2408930-A2 BIOTINIDASE ASSAY WALLAC OY (FI) 2012-01-25 EP claimed
WO-2010106222-A2 BIOTINIDASE ASSAY WALLAC OY (FI) 2010-09-23 WO claimed
EP-0664819-B1 CHELATING POLYMERS NYCOMED IMAGING AS (NO) 1997-08-06 EP claimed
US-5583206-A MODIFIED POLYALKYLENE OXIDES STERLING WINTHROP (US) 1996-12-10 US claimed
US-9505961-B2 Acrylic pressure sensitive adhesive composition, protection film including the same, polarizer and liquid crystal display LG CHEM, LTD. (KR) 2016-11-29 US disclosed
US-9505961-B2 Acrylic pressure sensitive adhesive composition, protection film including the same, polarizer and liquid crystal display LG CHEM, LTD. (KR) 2016-11-29 US disclosed
US-9499725-B2 Acrylic pressure-sensitive adhesive compositions LG CHEM, LTD. (KR) 2016-11-22 US disclosed
US-9499725-B2 Acrylic pressure-sensitive adhesive compositions LG CHEM, LTD. (KR) 2016-11-22 US disclosed
US-9383481-B2 Liquid crystal display LG CHEM, LTD. (KR) 2016-07-05 US disclosed
US-9383481-B2 Liquid crystal display LG CHEM, LTD. (KR) 2016-07-05 US disclosed
US-20100188620-A1 ACRYLIC PRESSURE-SENSITIVE ADHESIVE COMPOSITIONS LG CHEM, LTD. (KR) 2010-07-29 US disclosed
US-20100188620-A1 ACRYLIC PRESSURE-SENSITIVE ADHESIVE COMPOSITIONS LG CHEM, LTD. (KR) 2010-07-29 US disclosed
US-7482444-B2 Terminating substrates for DNA polymerases WALLAC OY (FI) 2009-01-27 US disclosed
WO-2007122291-A1 TITANOCENES FOR LABELLING BIOSPECIFIC BINDING REACTANTS WALLAC OY (FI) 2007-11-01 WO disclosed
US-20070248973-A1 Terminating substrates for DNA polymerases WALLAC OY (FI) 2007-10-25 US disclosed
US-7282581-B2 Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof WALLAC OY (FI) 2007-10-16 US disclosed
WO-2007104834-A1 TERMINATING SUBSTRATES FOR DNA POLYMERASES WALLAC OY (FI) 2007-09-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070248973-A1 Terminating substrates for DNA polymerases POLN, POLM, POLRMT NPSR1 2998/4885TDP1 53/4885ALOX15 4454/4885
US-20120045784-A1 BIOTINIDASE ASSAY BTD, CMBL, JMJD7 NPSR1 3316/4885TDP1 2853/4885ALOX15 3083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.