Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051041 | 0.77 | SLC6A2 (0.44) | GID4PRCPSLC6A2ADRA1AHTR2B | |
| SCHEMBL3769660 | 0.74 | CYP19A1 (0.39) | — | |
| SCHEMBL11493571 | 0.71 | SLC6A2 (0.40) | GID4SMN1; SMN2PRCPSLC6A2ADRA1A | |
| SCHEMBL23136984 | 0.69 | PRKACA (0.45) | GID4SMN1; SMN2SLC6A2ADRA1AHTR2B | |
| SCHEMBL30463847 | 0.69 | PRKACA (0.45) | GID4SMN1; SMN2SLC6A2ADRA1AHTR2B | |
| SCHEMBL15111039 | 0.69 | SLC6A2 (0.38) | GID4PRCPSLC6A2ADRA1AHTR2B | |
| SCHEMBL28831344 | 0.68 | PRCP (0.62) | GID4SMN1; SMN2PRCPHTR2BGAA | |
| Oxazolidine SCHEMBL14720881 | 0.67 | SLC6A2 (0.36) | GID4PRCPSLC6A2ADRA1AHTR2B | |
| SCHEMBL27407366 | 0.67 | TDP1 (0.43) | PRCPGAAMAPTALDH1A1 | |
| SCHEMBL25628128 | 0.66 | GID4 (0.43) | GID4SMN1; SMN2PRCPGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7847096-B2 | 4-aminophenylmorpholinone derivatives and their preparation | SALTIGO GMBH (DE) | 2010-12-07 | — | — | US | disclosed |
| US-7847096-B2 | 4-aminophenylmorpholinone derivatives and their preparation | SALTIGO GMBH (DE) | 2010-12-07 | — | — | US | disclosed |
| US-7504500-B2 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | MERCK PATENT GMBH (DE) | 2009-03-17 | — | — | US | disclosed |
| US-20090018126-A1 | 4-Aminophenylmorpholinone Derivatives and Their Preparation | SALTIGO GMBH (DE) | 2009-01-15 | — | — | US | disclosed |
| US-20090018126-A1 | 4-Aminophenylmorpholinone Derivatives and Their Preparation | SALTIGO GMBH (DE) | 2009-01-15 | — | — | US | disclosed |
| EP-1608646-B1 | METHOD FOR THE PRODUCTION OF PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-(PHENYL(-AMIDE))-2-(PHENYL(-AMIDE)) DERIVATIVES AND 1-(PHENYLCARBAMOYL)-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS INTERMEDIATE PRODUCTS | MERCK PATENT GMBH (DE) | 2007-07-11 | — | — | EP | disclosed |
| EP-1760081-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | Merck Patent GmbH (DE) | 2007-03-07 | — | — | EP | disclosed |
| US-20060211692-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | MERCK PATENT GMBH (DE) | 2006-09-21 | — | — | US | disclosed |
| EP-1608646-A1 | METHOD FOR THE PRODUCTION OF PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-(PHENYL(-AMIDE))-2-(PHENYL(-AMIDE)) DERIVATIVES AND 1-(PHENYLCARBAMOYL)-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS INTERMEDIATE PRODUCTS | MERCK PATENT GmbH (DE) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004087695-A1 | METHOD FOR THE PRODUCTION OF PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-(PHENYL(-AMIDE))-2-(PHENYL(-AMIDE)) DERIVATIVES AND 1-(PHENYLCARBAMOYL)-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS INTERMEDIATE PRODUCTS | MERCK PATENT GMBH (DE) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018126-A1 | 4-Aminophenylmorpholinone Derivatives and Their Preparation | HTR3C, ADRA2C, OPRM1 | GID4 1745/4885SMN1; SMN2 1025/4885PARP1 851/4885 |
| US-20060211692-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | PDHA2, PDHA1, CPS1 | GID4 4706/4885SMN1; SMN2 2306/4885PARP1 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.