Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.40 |
| ▸ | HTR2C | P28335 | 7/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | KMO | O15229 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3779615 | 0.85 | KMO (0.42) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL3784975 | 0.83 | CHRM2 (0.41) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL8007547 | 0.77 | HTR2A (0.55) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL6741175 | 0.77 | HTR2A (0.46) | HTR2AHTR2CHTR2BKMOHTR1A | |
| Ammonia Solution, Strong SCHEMBL8009916 | 0.76 | HTR2A (0.45) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL8007696 | 0.73 | HTR2A (0.54) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL8007544 | 0.73 | HTR2C (0.69) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL8009907 | 0.73 | HTR2C (0.69) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL78430 | 0.72 | REN (0.50) | HTR2AHTR2CHTR2BKMOHTR1A | |
| SCHEMBL2144057 | 0.71 | NOTUM (0.44) | HTR2AHTR2CHTR2BKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084485-B2 | 6-(aminoalkyl)indazoles | VITAE PHARMACEUTICALS, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100331287-A1 | 6-(Aminoalkyl)Indazoles | VITAE PHARMACEUTICALS, INC. | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331287-A1 | 6-(Aminoalkyl)Indazoles | REN, AGTR1, AGTR2 | HTR2A 1966/4885HTR2C 1984/4885HTR2B 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.