Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3782670 | 0.88 | PGAM1 (0.58) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL15501056 | 0.75 | HSD17B3 (0.49) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL3779672 | 0.74 | PGAM1 (0.58) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL3782322 | 0.72 | CLK2 (0.63) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL3778775 | 0.71 | ALDH1A1 (0.75) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL11493552 | 0.71 | ALDH1A1 (0.60) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL20957619 | 0.70 | HSD17B3 (0.58) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL5421595 | 0.70 | RXRA (0.61) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL7920448 | 0.69 | GAA (0.61) | ALDH1A1GAAKDM4EHPGDCASP1 | |
| SCHEMBL8745756 | 0.69 | KDM4E (0.64) | ALDH1A1GAAKDM4EHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896492-B | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof | INST OF MATARIA MEDICA CHINESE | 2015-05-06 | — | — | CN | disclosed |
| EP-2216335-B1 | TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2014-03-12 | — | — | EP | disclosed |
| EP-2216335-B1 | TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2014-03-12 | — | — | EP | disclosed |
| CN-101100470-B | Tetracyclic bispyranyl coumarin compounds | INST MATERIA MEDICA CAMS | 2013-02-13 | — | — | CN | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| CN-101896492-A | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof | INST OF MATARIA MEDICA CHINESE | 2010-11-24 | — | — | CN | disclosed |
| EP-2216335-A1 | TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | Institute of Mataria Medica, Chinese Academy of Medical Sciences (CN) | 2010-08-11 | — | — | EP | disclosed |
| CN-101100470-A | Tetracyclic bispyranyl coumarin compounds | INST MATERIA MEDICA CAMS (CN) | 2008-01-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | TBCB, TBC1D15, TBC1D5 | ALDH1A1 482/4885GAA 2093/4885KDM4E 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.