Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.45 |
| ▸ | THRA | P10827 | 8/20 | 0.45 |
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784791 | 0.89 | THRA (0.41) | THRBTHRAKMT2AMEN1ALDH1A1 | |
| SCHEMBL3705284 | 0.88 | THRB (0.44) | THRBTHRARORCALDH1A1KDM4E | |
| SCHEMBL3710195 | 0.88 | THRB (0.60) | THRBTHRAEPHX1EPHX2 | |
| SCHEMBL3803418 | 0.83 | THRB (0.44) | THRBTHRARORCKMT2AALDH1A1 | |
| SCHEMBL3812541 | 0.80 | THRB (0.44) | THRBTHRARORCKMT2AMEN1 | |
| SCHEMBL3714422 | 0.80 | THRB (0.44) | THRBTHRA | |
| SCHEMBL3702776 | 0.79 | THRB (0.58) | THRBTHRARORC | |
| SCHEMBL3226580 | 0.78 | THRB (0.42) | THRBTHRARORCKMT2AALDH1A1 | |
| SCHEMBL3707379 | 0.77 | RORC (0.57) | THRBTHRARORC | |
| SCHEMBL3782122 | 0.77 | THRB (0.47) | THRBTHRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |