Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13011491 | 0.93 | SCARB1 (0.45) | SCARB1ADRA1DADRA1AADRA1BKIF11 | |
| SCHEMBL13011492 | 0.93 | SCARB1 (0.45) | SCARB1ADRA1DADRA1AADRA1BKIF11 | |
| SCHEMBL13635683 | 0.93 | SCARB1 (0.45) | SCARB1ADRA1DADRA1AADRA1BKIF11 | |
| SCHEMBL3774230 | 0.88 | HSD11B1 (0.44) | SCARB1ADRA1DADRA1AADRA1BKIF11 | |
| SCHEMBL3780734 | 0.88 | HSD11B1 (0.44) | SCARB1KIF11HSD11B1OPRM1OPRD1 | |
| SCHEMBL3805093 | 0.88 | ALDH1A1 (0.43) | SCARB1ADRA1DADRA1AADRA1BKIF11 | |
| SCHEMBL13635205 | 0.88 | ALDH1A1 (0.51) | SCARB1KIF11OPRM1OPRD1OPRK1 | |
| SCHEMBL13011205 | 0.88 | ALDH1A1 (0.51) | SCARB1KIF11OPRM1OPRD1OPRK1 | |
| SCHEMBL13011202 | 0.88 | ALDH1A1 (0.51) | SCARB1KIF11OPRM1OPRD1OPRK1 | |
| SCHEMBL3775032 | 0.87 | NPC1 (0.51) | CNR2MEN1KMT2AALDH1A1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324017-A1 | ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100324017-A1 | ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-12-23 | — | — | US | disclosed |
| CN-101627013-A | Acylguanidine derivative | ASTELLAS PHARMA INC | 2010-01-13 | — | — | CN | disclosed |
| EP-2119704-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324017-A1 | ACYLGUANIDINE DERIVATIVE | HTR5A, GRM5, HTR1E | SCARB1 1612/4885ADRA1D 307/4885ADRA1A 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.