Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30053533 | 0.78 | PDPK1 (0.61) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL8272 | 0.78 | PDPK1 (0.61) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL1898183 | 0.77 | GDA (0.41) | CDK2PDPK1GDAMAP3K5XDH | |
| SCHEMBL16146458 | 0.77 | CDK2 (0.47) | CDK2PDPK1LRRK2GDAMAP3K5 | |
| Xanthine SCHEMBL4966 | 0.76 | GDA (0.44) | CDK2PDPK1LRRK2GDAMAP3K5 | |
| Xanthine SCHEMBL9443819 | 0.76 | GDA (0.44) | CDK2PDPK1LRRK2GDAMAP3K5 | |
| Xanthine SCHEMBL7044234 | 0.75 | GDA (0.42) | CDK2PDPK1LRRK2GDAMAP3K5 | |
| SCHEMBL612211 | 0.73 | GDA (0.41) | CDK2PDPK1LRRK2GDAMAP3K5 | |
| SCHEMBL1009011 | 0.73 | XDH (0.56) | CDK2PDPK1GDAXDHDPP4 | |
| SCHEMBL1724116 | 0.73 | GDA (0.41) | CDK2PDPK1LRRK2GDAMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140303112-A1 | Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) | ENERGENESIS BIOMEDICAL CO., LTD (TW) | 2014-10-09 | — | — | US | claimed |
| US-12054768-B2 | Methods for detecting agglutination and compositions for use in practicing the same | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-08-06 | — | — | US | disclosed |
| CN-116492347-A | Compound for activating AMPK and application thereof | 华安医学股份有限公司 | 2023-07-28 | — | — | CN | disclosed |
| EP-4123031-A1 | METHODS FOR DETECTING AGGLUTINATION AND COMPOSITIONS FOR USE IN PRACTICING THE SAME | The Regents of The University of California (US) | 2023-01-25 | — | — | EP | disclosed |
| EP-3283638-B1 | METHODS FOR DETECTING AGGLUTINATION AND USE OF KITS IN PRACTICING THE SAME | UNIV CALIFORNIA (US) | 2022-06-08 | — | — | EP | disclosed |
| US-20210403978-A1 | METHODS FOR DETECTING AGGLUTINATION AND COMPOSITIONS FOR USE IN PRACTICING THE SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-30 | — | — | US | disclosed |
| US-11149296-B2 | Methods for detecting agglutination and compositions for use in practicing the same | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-10-19 | — | — | US | disclosed |
| US-20200263231-A1 | Fluorogenic dyes for high sensitivity DNA detection | Life Technologies Corporation | 2020-08-20 | — | — | US | disclosed |
| US-20200232005-A1 | Methods of Producing and Using Single-Stranded Deoxyribonucleic Acids and Compositions for Use in Practicing the Same | TAKARA BIO USA, INC. | 2020-07-23 | — | — | US | disclosed |
| US-10584363-B2 | Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same | TAKARA BIO USA, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| WO-2000055366-A1 | ELECTROPOLYMERIZABLE FILM, AND METHOD OF MAKING AND USE THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-09-21 | — | — | WO | disclosed |
| US-5968745-A | ELECTRODE OF SUBSTRATE HAVING ELECTROCONDUCTIVE WORKING SURFACE AND A NONCONDUCTIVE OUTER POLYMER LAYER WHERE PROBES CAN BE ATTACHED HAVING MICROFLUIDIC REACTION OPENINGS FOR TRANSITION METAL COMPLEX TO TRANSFER ELECTRONS TO SURFACE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-10-19 | — | — | US | disclosed |
| US-5871918-A | DNA AND RNA HYBRIDIZATION DETECTION BY REACTION WITH TRANSITION METAL COMPLEX FOR OXIDATION-REDUCTION REACTION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0871773-A2 | ELECTROCHEMICAL DETECTION OF NUCLEIC ACID HYBRIDIZATION | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-10-21 | — | — | EP | disclosed |
| CN-1192249-A | Electrochemical detection of nucleic acid hybridization | UNIV NORTH CAROLINA (US) | 1998-09-02 | — | — | CN | disclosed |
| US-5719031-A | MEASURING FLUORESCENCE | MOLECULAR PROBES, INC. (US) | 1998-02-17 | — | — | US | disclosed |
| US-5658751-A | SUBSTITUENTS ON PYRIDINIUM OR QUINOLINIUM RING SYSTEM SERVE TO INCREASE OR DECREASE PERMEABILITY, SELECTIVITY AND BINDING AFFINITY OF NUCLEIC ACID STAINS; FORM FLUORESCENT COMPLEXES WITH NUCLEIC ACIDS | MOLECULAR PROBES, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5656449-A | STAINING NUCLEIC ACIDS | MOLECULAR PROBES, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| WO-1997001646-A2 | ELECTROCHEMICAL DETECTION OF NUCLEIC ACID HYBRIDIZATION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-01-16 | — | — | WO | disclosed |
| WO-1996013552-A2 | SUBSTITUTED UNSYMMETRICAL CYANINE DYES WITH SELECTED PERMEABILITY | MOLECULAR PROBES, INC. (US) | 1996-05-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303112-A1 | Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) | PRKAG2, PRKAB2, PRKAG1 | CDK2 1757/4885PDPK1 281/4885CHEK1 2344/4885 |
| US-20200263231-A1 | Fluorogenic dyes for high sensitivity DNA detection | POLRMT, POLM, DNMT3A | CDK2 1374/4885PDPK1 3905/4885CHEK1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.