SCHEMBL378339

SCHEMBL378339

Cc1cc(C=O)cc(C)n1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.42
CYP2A6 P11509 4/20 0.42
ALDH1A1 P00352 3/20 0.38
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
CYP1A2 P05177 2/20 0.33
TSHR P16473 1/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
HTT P42858 1/20 0.32
TYR P14679 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29953912 0.84 SRC (0.36) SRCCYP2A6ALDH1A1LMNAPOLB
SCHEMBL31039285 0.84 ALDH1A1 (0.38) SRCCYP2A6ALDH1A1LMNAPOLB
SCHEMBL18266291 0.84 NOS2 (0.52) SRCCYP2A6ALDH1A1NOS3NOS1
SCHEMBL29951624 0.84 SRC (0.40) SRCCYP2A6ALDH1A1LMNAHTT
SCHEMBL1043931 0.84 ALDH1A1 (0.38) SRCCYP2A6ALDH1A1LMNAPOLB
SCHEMBL12990369 0.84 SRC (0.36) SRCCYP2A6ALDH1A1LMNAPOLB
SCHEMBL31039438 0.84 SRC (0.36) SRCCYP2A6ALDH1A1LMNAPOLB
SCHEMBL2746692 0.80 NOS3 (0.38) SRCCYP2A6ALDH1A1LMNANOS3
SCHEMBL1619663 0.80 CYP1A2 (0.41) SRCCYP2A6ALDH1A1LMNAPOLB
SCHEMBL21715686 0.80 NOS3 (0.38) SRCCYP2A6ALDH1A1LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288091-B1 COMPOUNDS SUCH AS 2,2,2-TRICHLOROETHYL N-(4-(2-AMINO-4-THIAZOLYL)-PHENYL)CARBAMATE THAT INHIBIT THE HERPES HELCASE-PRIMASE ENZYME COMPLEX BOEHRINGER INGELHEIM LTD. (CA) 2001-09-11 US claimed
EP-4126835-B1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-02-18 EP disclosed
US-12516038-B2 Inhibitors of antigen presentation by HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-01-06 US disclosed
US-20250313561-A1 NEXT-GENERATION MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) RYVU THERAPEUTICS S A (PL) 2025-10-09 US disclosed
US-12421224-B2 Azetidinyl O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors BIOGEN MA INC. (US) 2025-09-23 US disclosed
US-12344606-B2 Next-generation modulators of stimulator of interferon genes (STING) Ryvu Therapeutics S.A. (PL) 2025-07-01 US disclosed
EP-2408454-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2024-07-24 EP disclosed
US-20240174651-A1 COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2024-05-30 US disclosed
CN-117355303-A Compounds and their use for the treatment of neurodegenerative, degenerative and metabolic disorders 佛罗里达大学研究基金会公司 2024-01-05 CN disclosed
EP-4284372-A1 COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS University of Florida Research Foundation, Incorporated (US) 2023-12-06 EP disclosed
CN-1246858-A Substituted pyrimidine compounds and their use AMGEN INC (US) 2000-03-08 CN disclosed
CN-1246857-A Substituted pyrimidinone and pyridinone compounds and their use AMGEN INC (US) 2000-03-08 CN disclosed
EP-0974602-A1 Catalyst and process for hydrogenating olefinically unsaturated compound JSR Corporation (JP) 2000-01-26 EP disclosed
CN-1242773-A Ticyclic carbapenem compound GLAXO WELLCOME SPA (IT) 2000-01-26 CN disclosed
EP-0948497-A2 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE Amgen inc. (US) 1999-10-13 EP disclosed
EP-0937078-A1 TRICYCLIC CARBAPENEM COMPOUNDS GLAXO WELLCOME S.p.A. (IT) 1999-08-25 EP disclosed
WO-1998024782-A2 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AMGEN INC. (US) 1998-06-11 WO disclosed
WO-1998021210-A1 TRICYCLIC CARBAPENEM COMPOUNDS GLAXO WELLCOME S.P.A. (IT) 1998-05-22 WO disclosed
US-4125530-A FROM 1,1-DIHALO-3,3,3-TRIFLUOROACETONE, BASE, AMMONIA AND A CARBOXALDEHYDE MERCK & CO., INC. (US) 1978-11-14 US disclosed
US-4032522-A ANTI-GOUT, ANTI-HYPERURICEMIC MERCK & CO., INC. (US) 1977-06-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12344606-B2 Next-generation modulators of stimulator of interferon genes (STING) STING1, IRF3, CGAS SRC 3006/4885CYP2A6 2313/4885ALDH1A1 4562/4885
US-20240174651-A1 COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE, DEGENERATIVE AND METABOLIC DISORDERS NLN, OAT, PC SRC 4051/4885CYP2A6 1210/4885ALDH1A1 424/4885
US-12421224-B2 Azetidinyl O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors UGGT1, MAN2A1, MAN2B2 SRC 2191/4885CYP2A6 544/4885ALDH1A1 405/4885
US-20250313561-A1 NEXT-GENERATION MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) STING1, IRF3, CGAS SRC 3006/4885CYP2A6 2313/4885ALDH1A1 4562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.