SCHEMBL3783548

SCHEMBL3783548

CC(=O)Oc1ccc(-c2cccc(N)c2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.65
GAA P10253 1/20 0.65
MAPT P10636 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
HPGD P15428 1/20 0.53
POLB P06746 1/20 0.53
HSD17B10 Q99714 1/20 0.53
GFER P55789 1/20 0.51
MAOA P21397 1/20 0.50
MCL1 Q07820 1/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA9 Q16790 1/20 0.47
CYP3A4 P08684 2/20 0.47
CYP17A1 P05093 1/20 0.47
CYP19A1 P11511 1/20 0.47
CYP11B1 P15538 1/20 0.47
CYP11B2 P19099 1/20 0.47
MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6207157 0.88 MAOA (0.57) LMNAGAAMAPTTDP1HPGD
SCHEMBL3789424 0.88 LMNA (0.56) LMNAGAAMAPTTDP1MAOA
SCHEMBL4960001 0.86 LMNA (0.71) LMNAGAAMAPTTDP1HPGD
SCHEMBL3788510 0.85 LMNA (0.48) LMNAGAAMAPTTDP1HPGD
SCHEMBL4607313 0.84 LMNA (0.71) LMNAGAAMAPTTDP1HPGD
SCHEMBL3781402 0.83 LMNA (0.56) LMNAGAAMAPTTDP1HPGD
SCHEMBL3790234 0.82 HSD17B10 (0.63) LMNAGAAMAPTTDP1POLB
Acetic Acid SCHEMBL4631069 0.82 HDAC2 (0.54) LMNAHPGDMAOAMCL1CYP3A4
SCHEMBL3787833 0.81 GAPDH (0.46) LMNAGAAMAPTTDP1POLB
SCHEMBL3787458 0.81 BACE1 (0.48) LMNAGAAMAPTTDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 LMNA 3250/4885GAA 1755/4885MAPT 3312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.