Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.79 |
| ▸ | RAB9A | P51151 | 5/20 | 0.76 |
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.61 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | SMO | Q99835 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13576533 | 0.88 | MEN1 (0.64) | GRM4RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL3790049 | 0.87 | MAPT (0.83) | GRM4RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL13219574 | 0.87 | MAPT (1.00) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL30369807 | 0.86 | NPC1 (1.00) | GRM4RAB9ANPC1MAPTKDM4E | |
| SCHEMBL4254257 | 0.86 | NPC1 (1.00) | GRM4RAB9ANPC1MAPTKDM4E | |
| SCHEMBL6351472 | 0.86 | GRM4 (0.62) | GRM4RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL6815327 | 0.85 | ALDH1A1 (0.60) | GRM4RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL8804658 | 0.85 | KDM4E (0.82) | GRM4RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL9362200 | 0.84 | HDAC1 (0.68) | GRM4RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL6819319 | 0.84 | ALDH1A1 (0.59) | GRM4RAB9ANPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-20100087680-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2010-04-08 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| EP-1914221-A1 | PROCESS FOR PRODUCING BIARYL COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | HMOX1, HMOX2, NOD2 | GRM4 2893/4885RAB9A 3460/4885NPC1 2200/4885 |
| US-20100087680-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | NISCH, BLVRB, BBOX1 | GRM4 2608/4885RAB9A 1357/4885NPC1 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.