Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379431 | 0.79 | SIGMAR1 (0.51) | HTR6SIGMAR1HTR3EHTR3BTSHR | |
| SCHEMBL5717885 | 0.74 | SIGMAR1 (0.45) | HTR6HTR2CSIGMAR1HTR3EHTR3B | |
| SCHEMBL4299855 | 0.73 | SIGMAR1 (0.42) | HTR2CSIGMAR1HTR3EHTR3BTSHR | |
| SCHEMBL3576603 | 0.73 | ALDH1A1 (0.62) | HTR2CSIGMAR1LMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5849112 | 0.73 | SIGMAR1 (0.44) | HTR6HTR2CSIGMAR1HTR3EHTR3B | |
| SCHEMBL4299853 | 0.72 | SIGMAR1 (0.38) | HTR6HTR2CSIGMAR1HTR3EHTR3B | |
| SCHEMBL9548533 | 0.72 | NR4A1 (0.60) | NR4A1NR4A2NR4A3HTR2CSIGMAR1 | |
| Hydrochloric Acid SCHEMBL9035292 | 0.72 | ALDH1A1 (0.61) | HTR2CSIGMAR1LMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL1193388 | 0.72 | ALDH1A1 (0.61) | HTR2CSIGMAR1LMNAKDM4EALDH1A1 | |
| SCHEMBL17295878 | 0.71 | OPRD1 (0.43) | SIGMAR1CYP2D6TSHRHSD17B10OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101056878-A | Azaindole carboxamides | SCHVARZ PHARMA AG (DE) | 2007-10-17 | — | — | CN | disclosed |
| CN-101027294-A | Phenyl DIAZEPAN carboxamides and annelated phenyl piperazine carboxamides containing oxygen and used as dopamine D3 antagonists | SANOL ARZNEI SCHWARZ GMBH (DE) | 2007-08-29 | — | — | CN | disclosed |
| CN-101014599-A | Indolizine carboxamides and the aza and diaza derivatives thereof | SANOL ARZNEI SCHWARZ GMBH (DE) | 2007-08-08 | — | — | CN | disclosed |
| US-20050197343-A1 | Utilization of heteroarene carboxamide as dopamine-d3 ligands for the treatment of cns diseases | SCHWARZ PHARMA AG (DE) | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197343-A1 | Utilization of heteroarene carboxamide as dopamine-d3 ligands for the treatment of cns diseases | SLC6A3, DRD2, ADH1A | BACE1 2821/4885NR4A1 439/4885NR4A2 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.