Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29907612 | 0.83 | NPC1 (0.50) | GSK3BSIRT6HPGDSP2RY14KMT2A | |
| SCHEMBL3347682 | 0.76 | KMT2A (0.49) | GSK3BHPGDSP2RY14KMT2ANPY5R | |
| SCHEMBL2933552 | 0.75 | LDHA (0.53) | LDHAGSK3BSIRT6TSHRKDM4E | |
| SCHEMBL2635320 | 0.74 | SIRT6 (0.73) | GSK3BSIRT6ADORA3TSHRMC4R | |
| Hydrochloric Acid SCHEMBL27917292 | 0.72 | SIRT6 (0.70) | GSK3BSIRT6ADORA3TSHRMC4R | |
| SCHEMBL379466 | 0.72 | FEN1 (0.47) | LDHAALOX5APFEN1 | |
| SCHEMBL28045606 | 0.71 | SIRT6 (0.44) | GSK3BSIRT6HPGDSADORA3TSHR | |
| SCHEMBL28777569 | 0.70 | GRM5 (0.50) | GSK3BHPGDSADORA3TSHRMC4R | |
| SCHEMBL3744416 | 0.70 | NPC1 (0.51) | KDM4EASPHKDM8KMOMAP4K4 | |
| SCHEMBL3625940 | 0.69 | HPGDS (0.44) | LDHAGSK3BHPGDSMAP4K4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408767-B1 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | LUNDBECK & CO AS H (DK) | 2013-07-10 | — | — | EP | claimed |
| CN-102356079-A | Amide derivatives as neuropeptide y5 receptor ligands | LUNDBECK & CO AS H | 2012-02-15 | — | — | CN | claimed |
| EP-2408767-A2 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | H. Lundbeck A/S (DK) | 2012-01-25 | — | — | EP | claimed |
| WO-2010108052-A2 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | H. LUNDBECK A/S (DK) | 2010-09-23 | — | — | WO | claimed |
| EP-2408767-B1 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | LUNDBECK & CO AS H (DK) | 2013-07-10 | — | — | EP | disclosed |
| CN-102356079-A | Amide derivatives as neuropeptide y5 receptor ligands | LUNDBECK & CO AS H | 2012-02-15 | — | — | CN | disclosed |
| WO-2010108052-A2 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | H. LUNDBECK A/S (DK) | 2010-09-23 | — | — | WO | disclosed |