Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380793 | 0.80 | HTR2C (0.39) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL15061430 | 0.79 | GPR35 (0.42) | GPR35NSD2 | |
| SCHEMBL18325638 | 0.78 | HSD17B1 (0.38) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL7233237 | 0.77 | NSD2 (0.53) | HTR2CSLC6A4CTSLCTSBCTSS | |
| SCHEMBL25363849 | 0.77 | CACNA1G (0.36) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL320434 | 0.76 | MEP1A (0.49) | HTR2CSLC6A4CTSLCTSBCTSS | |
| SCHEMBL16629778 | 0.75 | GPR119 (0.38) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL1187327 | 0.74 | ALDH1A1 (0.38) | ABCB1ALDH1A1GLACETPGPR35 | |
| SCHEMBL5912950 | 0.74 | ABCB1 (0.36) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL5912934 | 0.74 | HTT (0.45) | HTR2CSLC6A4MCHR1ABCB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| EP-2409977-A1 | AMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | CACNA1G 1069/4885CACNA1B 522/4885CACNA1C 689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.