Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812541 | 0.90 | THRB (0.44) | KMT2AMEN1GAAGLAEPHX1 | |
| SCHEMBL3805324 | 0.89 | THRA (0.46) | KMT2AEPHX1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3800984 | 0.83 | GYS1 (0.41) | KEAP1NFE2L2HPGDHTT | |
| SCHEMBL3806836 | 0.81 | KDM4E (0.41) | KEAP1NFE2L2KDM4EHPGDPOLB | |
| SCHEMBL3802151 | 0.81 | TSHR (0.40) | KMT2AKEAP1NFE2L2POLB | |
| SCHEMBL3784791 | 0.80 | THRA (0.41) | KMT2AMEN1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL3800631 | 0.80 | LMNA (0.38) | KMT2AMEN1KEAP1NFE2L2CD274 | |
| SCHEMBL3800512 | 0.79 | LMNA (0.42) | ALDH1A1KDM4EPOLBTDP1MAPK1 | |
| SCHEMBL3806790 | 0.78 | MEN1 (0.45) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL3702844 | 0.78 | THRB (0.58) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |